{"product_id":"gas2-antibody-growth-arrest-specific-protein-2-bha17136014","title":"GAS2 Antibody \/ Growth arrest specific protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGAS2 Antibody \/ Growth arrest specific protein 2 is a anti-GAS2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31G23 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GAS2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31G23, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGAS2 antibody detects Growth arrest specific protein 2, encoded by the GAS2 gene. Growth arrest specific protein 2 is a cytoskeletal regulator that stabilizes microfilaments and microtubules. It is expressed during cell cycle arrest and differentiation, linking cytoskeletal dynamics to growth regulation. GAS2 antibody provides researchers with a useful reagent for studying cell growth, apoptosis, and cancer biology.\u003cbr\u003e\u003cbr\u003eGrowth arrest specific protein 2 contains actin binding domains and microtubule binding motifs that allow it to crosslink cytoskeletal components. Research using GAS2 antibody has demonstrated that it stabilizes actin filaments and microtubules during cell cycle arrest, contributing to maintenance of cell shape and integrity. By coordinating cytoskeletal structures, GAS2 helps control cell migration, adhesion, and survival.\u003cbr\u003e\u003cbr\u003eIn addition to cytoskeletal regulation, GAS2 is involved in apoptosis. Studies with GAS2 antibody have shown that it is cleaved by caspases during programmed cell death, producing fragments that promote cytoskeletal disassembly. This links GAS2 function to apoptotic morphology, including cell shrinkage and membrane blebbing. Dysregulation of GAS2 expression or cleavage contributes to abnormal cell survival in disease.\u003cbr\u003e\u003cbr\u003eGAS2 has been studied in cancer, where its expression influences cell proliferation and migration. Research with GAS2 antibody has indicated that altered levels promote tumor progression by disrupting cytoskeletal control. Conversely, in some contexts GAS2 expression suppresses tumorigenesis by stabilizing growth arrest. This duality highlights its complex roles depending on cellular environment.\u003cbr\u003e\u003cbr\u003eGAS2 antibody is used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full length and cleaved forms, immunohistochemistry shows distribution in growth arrested tissues, and immunofluorescence reveals colocalization with actin and tubulin. These applications make GAS2 antibody valuable in studies of cell cycle, cytoskeletal dynamics, and apoptosis.\u003cbr\u003e\u003cbr\u003eBy providing validated GAS2 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GAS2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GAS2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GAS2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GAS2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GAS2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047312712045,"sku":"FY13112","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_df9d51ff-7e6e-49d2-8d63-aaf896f63a26.jpg?v=1772019396","url":"https:\/\/www.ebiohippo.com\/products\/gas2-antibody-growth-arrest-specific-protein-2-bha17136014","provider":"BioHippo","version":"1.0","type":"link"}