{"product_id":"gas2l2-antibody-growth-arrest-specific-protein-2-like-2-bha17135430","title":"GAS2L2 Antibody \/ Growth arrest-specific protein 2-like 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGAS2L2 Antibody \/ Growth arrest-specific protein 2-like 2 is a anti-GAS2L2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GAS2L2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGAS2L2 antibody detects Growth arrest-specific protein 2-like 2, a cytoskeletal-associated protein that links microtubules and actin filaments. GAS2L2 contributes to cell shape maintenance, mechanical stability, and tissue organization. The GAS2L2 antibody is used to study cytoskeleton interactions, cell polarity, and epithelial morphogenesis.\u003cbr\u003e\u003cbr\u003eGAS2L2 is encoded by the GAS2L2 gene on human chromosome 17p13.1. The protein is approximately 97 kilodaltons and contains a calponin homology (CH) domain that binds actin and a GAS2-related (GAR) domain that associates with microtubules. This dual-binding capability enables GAS2L2 to coordinate actin-microtubule crosslinking, influencing cell architecture and mechanotransduction.\u003cbr\u003e\u003cbr\u003eThe GAS2L2 antibody reveals filamentous and junctional staining in epithelial and smooth muscle cells. GAS2L2 expression is enriched in respiratory and reproductive epithelia, where it stabilizes apical cell-cell contacts. Loss of GAS2L2 disrupts ciliogenesis and planar cell polarity, leading to impaired epithelial alignment and fluid transport. In fibroblasts and neurons, GAS2L2 contributes to microtubule organization and axonal guidance.\u003cbr\u003e\u003cbr\u003eBeyond structural support, GAS2L2 regulates cell migration and wound healing by modulating actin polymerization dynamics. It interacts with signaling proteins that respond to mechanical stress, suggesting a role in tissue homeostasis and mechanosensitive pathways. Mutations or altered expression of GAS2L2 are associated with ciliary dysfunction and airway remodeling disorders.\u003cbr\u003e\u003cbr\u003eBecause of its crosslinking function, GAS2L2 serves as a molecular bridge between cytoskeletal networks, coordinating force generation and cellular tension.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GAS2L2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GAS2L2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GAS2L2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GAS2L2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GAS2L2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047291871597,"sku":"FY12527","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_25ece73d-a107-4c96-b1a9-84771fb0233d.jpg?v=1782237021","url":"https:\/\/www.ebiohippo.com\/products\/gas2l2-antibody-growth-arrest-specific-protein-2-like-2-bha17135430","provider":"BioHippo","version":"1.0","type":"link"}