{"product_id":"gas7-antibody-growth-arrest-specific-protein-7-bha17135660","title":"GAS7 Antibody \/ Growth arrest-specific protein 7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGAS7 Antibody \/ Growth arrest-specific protein 7 is a anti-GAS7 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GAS7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGAS7 antibody detects Growth arrest-specific protein 7, a cytoskeletal and signaling adapter protein involved in neuronal differentiation, cytoskeletal organization, and cell growth regulation. Encoded by the GAS7 gene on chromosome 17p13.1, this protein is part of the growth arrest-specific (GAS) gene family that is induced during cell cycle arrest. GAS7 contains WW and F-BAR domains that enable membrane deformation and actin cytoskeleton remodeling, supporting neurite outgrowth and cell shape changes. It is highly expressed in the nervous system, particularly in developing neurons and the cerebral cortex.\u003cbr\u003e\u003cbr\u003eGAS7 acts as a structural and regulatory protein linking signaling pathways to cytoskeletal remodeling. Its F-BAR domain promotes membrane tubulation and extension of cellular processes, while its WW domain mediates interaction with proline-rich signaling proteins. GAS7 facilitates neurite initiation and elongation by coordinating actin and microtubule dynamics. In non-neuronal cells, it contributes to growth arrest and differentiation through modulation of cytoskeletal tension. Its expression is upregulated during cell cycle exit and differentiation, suggesting a role in maintaining terminal cell identity.\u003cbr\u003e\u003cbr\u003eThe GAS7 antibody is used in neurobiology, developmental, and cancer research to detect Growth arrest-specific protein 7 expression and localization. Western blot analysis typically identifies a 48 kilodalton band, while immunofluorescence shows cytoplasmic and membrane-associated staining consistent with its role in actin remodeling. GAS7 is also studied for its involvement in leukemia, where chromosomal translocations involving GAS7 and transcription factors such as EWSR1 have been identified, indicating potential roles in oncogenic fusion gene formation.\u003cbr\u003e\u003cbr\u003eBeyond neuronal function, GAS7 is expressed in macrophages and fibroblasts where it regulates cell spreading, migration, and vesicle trafficking. The GAS7 antibody supports research into cytoskeletal signaling and differentiation control, particularly in studies of neuronal morphogenesis and actin network dynamics.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GAS7 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GAS7 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GAS7 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GAS7 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GAS7+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047299637613,"sku":"FY12757","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b2e48f3f-4731-45ec-b339-63c9aa11256d.jpg?v=1782237048","url":"https:\/\/www.ebiohippo.com\/products\/gas7-antibody-growth-arrest-specific-protein-7-bha17135660","provider":"BioHippo","version":"1.0","type":"link"}