{"product_id":"gasdermin-e-antibody-gsdme-dfna5-bha17128139","title":"Gasdermin E Antibody \/ GSDME \/ DFNA5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eGasdermin E Antibody \/ GSDME \/ DFNA5 is an antibody targeting \u003cstrong\u003eGSDME\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GSDME.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eGasdermin E, also known as GSDME or DFNA5, is a protein that was originally identified as a member of the gasdermin family, which are known for their role in inflammation and cell death. While other members of this family have been extensively studied, Gasdermin E remained relatively unexplored until recently. One of the most exciting findings regarding Gasdermin E is its role in pyroptosis, a form of cell death that is triggered by inflammasomes. Pyroptosis is a vital part of the immune response, as it helps to eliminate infected or damaged cells. Gasdermin E has been shown to be crucial for the execution of pyroptosis, acting as a pore-forming protein that allows for the release of pro-inflammatory cytokines and other molecules from the cell. In addition to its role in cell death, Gasdermin E has also been implicated in a variety of other cellular processes, including cell proliferation, migration, and differentiation. Studies have shown that dysregulation of Gasdermin E can contribute to the development of various diseases, such as cancer, autoimmune disorders, and neurodegenerative conditions.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry O60443 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/O60443 - Gene search: GSDME — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GSDME - Ensembl search: GSDME — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GSDME - PubMed search: GSDME antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GSDME+antibody - Reactome search: GSDME — Reactome — https:\/\/reactome.org\/content\/query?q=GSDME --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.05 ml","offer_id":53046411198829,"sku":"F55076-0.05ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.2 ml","offer_id":53046471131501,"sku":"F55076-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9e5dc308-57b6-4284-bf41-f2bd049fbd04.jpg?v=1772000494","url":"https:\/\/www.ebiohippo.com\/products\/gasdermin-e-antibody-gsdme-dfna5-bha17128139","provider":"BioHippo","version":"1.0","type":"link"}