{"product_id":"ggn-antibody-gametogenetin-bha17135627","title":"GGN Antibody \/ Gametogenetin","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGGN Antibody \/ Gametogenetin is a anti-GGN Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GGN\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGGN antibody detects Gametogenetin (also known as Gametogenetin protein), a testis-enriched protein that participates in germ cell differentiation and DNA repair during spermatogenesis. Encoded by the GGN gene on chromosome 19q13.33, this protein is predominantly expressed in spermatocytes and spermatids, where it contributes to chromatin organization, meiotic progression, and sperm maturation. Gametogenetin contains multiple coiled-coil domains and nuclear localization sequences, enabling interactions with DNA repair proteins and chromatin-associated complexes. It forms part of a multi-protein network essential for maintaining genome stability during meiosis.\u003cbr\u003e\u003cbr\u003eGametogenetin is highly conserved across mammals and plays a crucial role in spermatogenic cell viability. Studies have shown that GGN interacts with Fanconi anemia proteins and DNA polymerases, suggesting a role in homologous recombination repair. Disruption of GGN function results in defective sperm development and infertility in animal models. Its expression pattern, confined largely to the testis, makes it a useful molecular marker for germ cell differentiation and testicular function. The GGN antibody provides a key reagent for studying reproductive biology, meiotic regulation, and DNA damage response mechanisms in germ cells.\u003cbr\u003e\u003cbr\u003eIn addition to reproductive functions, low levels of GGN expression have been detected in certain somatic tissues, including brain and kidney, though its physiological significance there remains uncertain. The protein is localized primarily in the nucleus but may also associate with cytoplasmic vesicles during spermiogenesis. Western blot analysis using the GGN antibody identifies a ~70 kilodalton band, while immunohistochemistry reveals nuclear staining in spermatogenic cells within seminiferous tubules. The antibody is useful for distinguishing stages of spermatogenesis and assessing germ cell health in both normal and pathological conditions.\u003cbr\u003e\u003cbr\u003eBecause GGN interacts with DNA repair proteins, its dysregulation may contribute to genomic instability or subfertility. The GGN antibody enables detailed investigation of gametogenic processes and molecular pathways that maintain genome integrity in reproductive cells.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GGN - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GGN - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GGN - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GGN - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GGN+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047298589037,"sku":"FY12724","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_18c4ba47-e869-4af1-9cc0-28536888f6b8.jpg?v=1782237036","url":"https:\/\/www.ebiohippo.com\/products\/ggn-antibody-gametogenetin-bha17135627","provider":"BioHippo","version":"1.0","type":"link"}