{"product_id":"gh1-antibody-growth-hormone-bha17135453","title":"GH1 Antibody \/ Growth Hormone","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGH1 Antibody \/ Growth Hormone is a anti-GH1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GH1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGH1 antibody detects Growth hormone 1, a peptide hormone secreted by the anterior pituitary gland that stimulates growth, metabolism, and cellular regeneration. GH1 belongs to the somatotropin\/prolactin family of hormones and exerts its effects through activation of the growth hormone receptor (GHR) and downstream JAK-STAT signaling pathways. The GH1 antibody is used in endocrinology and metabolic research to study growth regulation, pituitary physiology, and hormone secretion mechanisms.\u003cbr\u003e\u003cbr\u003eGH1 is encoded by the GH1 gene located on human chromosome 17q24.2. The mature protein is approximately 22 kilodaltons and derived from a larger precursor that undergoes signal peptide removal and disulfide bond formation in the endoplasmic reticulum. GH1 is stored in secretory granules and released into circulation in response to hypothalamic growth hormone-releasing hormone (GHRH) and inhibited by somatostatin. It plays major roles in postnatal growth, bone development, and metabolic homeostasis.\u003cbr\u003e\u003cbr\u003eThe GH1 antibody detects the 22 kilodalton hormone by western blot and shows strong cytoplasmic granule staining in pituitary somatotrophs by immunofluorescence. GH1 binds to its receptor on target tissues, activating JAK2 and STAT5 pathways that induce insulin-like growth factor 1 (IGF1) production in the liver and peripheral tissues. Through IGF1 and direct signaling, GH1 stimulates protein synthesis, lipolysis, and glucose utilization.\u003cbr\u003e\u003cbr\u003eAberrations in GH1 production cause growth disorders, including gigantism and acromegaly from overproduction, or growth hormone deficiency due to pituitary malfunction or genetic mutation. Outside growth regulation, GH1 contributes to immune function, cardiac performance, and metabolic adaptation under stress conditions. Elevated GH1 and IGF1 signaling are also linked to cancer cell proliferation and survival.\u003cbr\u003e\u003cbr\u003eBecause of its central endocrine function, GH1 serves as a key biomarker in clinical diagnostics and metabolic studies.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GH1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GH1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GH1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GH1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GH1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047292100973,"sku":"FY12550","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b904cc57-0e41-46d0-a8e8-b94132624d7e.jpg?v=1782237030","url":"https:\/\/www.ebiohippo.com\/products\/gh1-antibody-growth-hormone-bha17135453","provider":"BioHippo","version":"1.0","type":"link"}