{"product_id":"gimap1-antibody-gtpase-imap-family-member-1-bha17136147","title":"GIMAP1 Antibody \/ GTPase IMAP family member 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGIMAP1 Antibody \/ GTPase IMAP family member 1 is a anti-GIMAP1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GIMAP1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGIMAP1 antibody detects GTPase IMAP family member 1, a small GTP-binding protein involved in lymphocyte survival and immune regulation. The UniProt recommended name is GTPase IMAP family member 1 (GIMAP1). This protein belongs to the GIMAP (GTPase of immunity-associated proteins) family, which participates in T-cell development, apoptosis resistance, and mitochondrial homeostasis within immune cells.\u003cbr\u003e\u003cbr\u003eFunctionally, GIMAP1 antibody identifies a 320-amino-acid cytoplasmic and mitochondrial membrane-associated GTPase. GIMAP1 regulates cell survival by maintaining mitochondrial integrity and preventing apoptotic signaling during lymphocyte maturation. It interacts with other GIMAP family members and BCL2-related proteins to modulate intrinsic apoptosis pathways. GIMAP1 expression is induced during T-cell activation and may help coordinate metabolic adaptation and survival under stress conditions.\u003cbr\u003e\u003cbr\u003eThe GIMAP1 gene is located on chromosome 7q36.1 and is expressed predominantly in thymus, spleen, and peripheral lymphocytes. Its expression pattern mirrors that of immune cell differentiation markers, underscoring its role in adaptive immunity. GIMAP1 acts as a key survival regulator in the transition of T-cells from double-positive to single-positive stages in the thymus.\u003cbr\u003e\u003cbr\u003ePathologically, GIMAP1 dysregulation has been linked to autoimmune disorders and lymphoid malignancies. Loss of function leads to increased apoptosis of lymphocytes and immunodeficiency, while overexpression contributes to T-cell survival in leukemia. Research using GIMAP1 antibody supports studies in immunology, cell survival pathways, and mitochondrial regulation in immune cells.\u003cbr\u003e\u003cbr\u003eGIMAP1 antibody is validated for western blotting, immunofluorescence, and flow cytometry to detect small GTPases involved in immune cell regulation. \u003cbr\u003e\u003cbr\u003eStructurally, GTPase IMAP family member 1 contains conserved GTP-binding motifs typical of small GTPases, including the P-loop, switch I, and switch II regions that mediate nucleotide binding and hydrolysis. Its membrane association and GTP-dependent conformational changes regulate interactions with mitochondrial and cytoskeletal components. This antibody enables detailed analysis of GIMAP1's role in immune homeostasis and cell survival signaling.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GIMAP1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GIMAP1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GIMAP1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GIMAP1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GIMAP1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319495021,"sku":"FY13245","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a356d6ee-ba65-4a53-b007-f996bf47b1af.jpg?v=1782237087","url":"https:\/\/www.ebiohippo.com\/products\/gimap1-antibody-gtpase-imap-family-member-1-bha17136147","provider":"BioHippo","version":"1.0","type":"link"}