{"product_id":"gipc1-antibody-pdz-domain-containing-protein-gipc1-bha17136179","title":"GIPC1 Antibody \/ PDZ domain-containing protein GIPC1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGIPC1 Antibody \/ PDZ domain-containing protein GIPC1 is a anti-GIPC1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, cell membrane, nucleus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GIPC1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC, IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGIPC1 antibody detects PDZ domain-containing protein GIPC1, a cytoplasmic adaptor protein that regulates receptor trafficking, cell signaling, and cytoskeletal organization. The UniProt recommended name is PDZ domain-containing protein GIPC1 (GIPC1). This multifunctional scaffold protein interacts with a wide variety of transmembrane receptors, G-protein coupled receptors, and signaling adaptors through its conserved PDZ domain, influencing signal transduction and vesicular transport.\u003cbr\u003e\u003cbr\u003eFunctionally, GIPC1 antibody identifies a 333-amino-acid protein that contains a central PDZ domain responsible for binding the C-terminal motifs of target proteins such as TGFbeta receptor III, GLUT1, and neuropilin-1. GIPC1 participates in endocytic recycling and intracellular trafficking of these receptors, thereby modulating cellular responses to growth factors, adhesion molecules, and hormones. Additionally, GIPC1 acts as a linker between membrane receptors and the actin cytoskeleton via interactions with myosin VI, regulating cell polarity and motility.\u003cbr\u003e\u003cbr\u003eThe GIPC1 gene is located on chromosome 19p13.12 and is expressed ubiquitously, with high levels found in epithelial, neuronal, and endothelial tissues. Its expression is regulated during development and by extracellular stimuli such as growth factors and oxidative stress. GIPC1 is essential for maintaining proper vesicle transport and receptor localization in diverse cell types.\u003cbr\u003e\u003cbr\u003ePathologically, altered GIPC1 expression has been implicated in cancer progression, angiogenesis, and neurological disorders. Overexpression in breast, pancreatic, and gastric cancers enhances tumor cell proliferation and migration by stabilizing growth factor receptor signaling. In neurons, dysregulated GIPC1 may disrupt synaptic vesicle trafficking and signaling. Research using GIPC1 antibody supports studies in receptor trafficking, cancer signaling, and cytoskeletal regulation.\u003cbr\u003e\u003cbr\u003eGIPC1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect adaptor proteins involved in signal transduction. \u003cbr\u003e\u003cbr\u003eStructurally, PDZ domain-containing protein GIPC1 includes an N-terminal GH1 domain for dimerization, a central PDZ domain for C-terminal binding to target proteins, and a C-terminal GH2 domain for myosin VI interaction. This modular structure enables GIPC1 to act as a versatile scaffold that coordinates endocytic transport and receptor-mediated signaling. This antibody enables exploration of GIPC1's role in intracellular trafficking, cancer progression, and signal compartmentalization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GIPC1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GIPC1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GIPC1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GIPC1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GIPC1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320346989,"sku":"FY13277","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_8658293f-9e37-42fd-a85f-296040570576.jpg?v=1782237085","url":"https:\/\/www.ebiohippo.com\/products\/gipc1-antibody-pdz-domain-containing-protein-gipc1-bha17136179","provider":"BioHippo","version":"1.0","type":"link"}