{"product_id":"glg1-antibody-golgi-apparatus-protein-1-bha17136131","title":"GLG1 Antibody \/ Golgi apparatus protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGLG1 Antibody \/ Golgi apparatus protein 1 is a anti-GLG1 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GLG1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGLG1 antibody detects Golgi apparatus protein 1, also known as Golgi glycoprotein 1 or E-selectin ligand 1, a type I transmembrane protein involved in protein trafficking, glycosylation, and cell adhesion. The UniProt recommended name is Golgi apparatus protein 1 (GLG1). This protein serves as a key component of the Golgi matrix and participates in sorting and processing of glycoproteins destined for secretion or membrane localization.\u003cbr\u003e\u003cbr\u003eFunctionally, GLG1 antibody identifies a 1,474-amino-acid type I membrane glycoprotein containing multiple FG (phenylalanine-glycine)-like and epidermal growth factor (EGF)-like repeats. GLG1 acts as a recycling receptor in the Golgi, binding fibroblast growth factors (FGFs) and contributing to their intracellular trafficking. It also functions as a ligand for E-selectin, mediating leukocyte adhesion to endothelial cells during inflammation. Within the Golgi, GLG1 organizes cisternal structure and assists in the retrieval of escaped proteins from post-Golgi compartments.\u003cbr\u003e\u003cbr\u003eThe GLG1 gene is located on chromosome 16q22.1 and is widely expressed in epithelial, endothelial, and secretory tissues. Its expression is tightly regulated by growth factors and stress signals, ensuring efficient vesicular transport and glycoprotein processing.\u003cbr\u003e\u003cbr\u003ePathologically, GLG1 dysregulation has been linked to cancer progression, congenital disorders of glycosylation, and inflammatory diseases. Overexpression promotes tumor cell migration and metastasis by enhancing adhesion to E-selectin and modulating FGF signaling. Conversely, reduced GLG1 disrupts protein trafficking and Golgi integrity. Research using GLG1 antibody supports studies in vesicular transport, cell adhesion, and tumor biology.\u003cbr\u003e\u003cbr\u003eGLG1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect Golgi-associated proteins. \u003cbr\u003e\u003cbr\u003eStructurally, Golgi apparatus protein 1 contains a long luminal region with repetitive domains, a single transmembrane helix, and a short cytoplasmic tail responsible for Golgi retention. The protein's modular structure supports both structural and signaling functions within secretory pathways. This antibody enables exploration of GLG1's role in Golgi function, protein sorting, and inflammatory cell adhesion.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GLG1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GLG1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GLG1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GLG1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GLG1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047319396717,"sku":"FY13229","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_64fbd345-c7ff-4880-a570-227795c8898d.jpg?v=1782237087","url":"https:\/\/www.ebiohippo.com\/products\/glg1-antibody-golgi-apparatus-protein-1-bha17136131","provider":"BioHippo","version":"1.0","type":"link"}