{"product_id":"glipr2-antibody-gli-pathogenesis-related-protein-2-bha17135858","title":"GLIPR2 Antibody \/ GLI pathogenesis-related protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGLIPR2 Antibody \/ GLI pathogenesis-related protein 2 is a anti-GLIPR2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Flow cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western blot (WB) with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GLIPR2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e ELISA, FACS, IP, IHC, WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGLIPR2 antibody detects GLI pathogenesis-related protein 2, a member of the pathogenesis-related (PR-1) protein superfamily implicated in autophagy regulation, cellular stress response, and tumor progression. The UniProt recommended name is GLI pathogenesis-related protein 2 (GLIPR2), also known as Golgi-associated plant pathogenesis-related protein 1 domain-containing protein 2 (GAPR-1). GLIPR2 is a lipid raft-associated protein predominantly localized to the Golgi apparatus and cytoplasmic membranes, where it contributes to membrane homeostasis and cell survival pathways.\u003cbr\u003e\u003cbr\u003eFunctionally, GLIPR2 antibody recognizes a 172-amino-acid protein that plays a dual role in regulating autophagy and cellular differentiation. GLIPR2 interacts with Beclin-1, a central component of the autophagy initiation complex, to modulate autophagosome formation. Overexpression of GLIPR2 inhibits autophagic flux, whereas its depletion enhances autophagy under stress conditions. This regulatory balance links GLIPR2 to processes such as tumor suppression, cell death, and immune modulation. The protein is expressed in multiple tissues, including liver, kidney, and lung, and its expression is inducible under oxidative or endoplasmic reticulum stress.\u003cbr\u003e\u003cbr\u003eThe GLIPR2 gene is located on chromosome 9p13.3 and encodes a secreted and membrane-associated protein characterized by a conserved CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1) domain. This structural motif enables interactions with lipids, membranes, and signaling proteins, mediating responses to cellular stress. GLIPR2 is known to form homodimers and is subject to regulation by cholesterol content in the Golgi membrane. This localization allows it to influence vesicle trafficking and protein processing under metabolic challenge.\u003cbr\u003e\u003cbr\u003eGLIPR2 antibody is widely used in research investigating autophagy, lipid homeostasis, and tumor biology. In cancer studies, GLIPR2 functions as a modulator of epithelial-to-mesenchymal transition (EMT), influencing cell adhesion, migration, and invasion. Dysregulated GLIPR2 expression has been linked to aggressive tumor phenotypes, including hepatocellular carcinoma and renal cell carcinoma. In non-cancer contexts, GLIPR2 participates in innate immune regulation and Golgi stress adaptation. It also contributes to lung tissue integrity by modulating surfactant secretion and inflammatory signaling.\u003cbr\u003e\u003cbr\u003eAt the molecular level, GLIPR2 interacts with proteins involved in oxidative stress response and chaperone-assisted folding. Its CAP domain facilitates binding to phosphatidylinositol lipids, anchoring it to specific membrane compartments. The GLIPR2 antibody is an essential tool for detecting this protein in cell biology, immunofluorescence, and immunoblotting applications. Its detection assists in understanding Golgi function, autophagy balance, and membrane organization under normal and pathological conditions.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GLIPR2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GLIPR2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GLIPR2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GLIPR2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GLIPR2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047307796845,"sku":"FY12956","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a40a8f14-dd3c-4877-8429-778a5c69b097.jpg?v=1782237072","url":"https:\/\/www.ebiohippo.com\/products\/glipr2-antibody-gli-pathogenesis-related-protein-2-bha17135858","provider":"BioHippo","version":"1.0","type":"link"}