{"product_id":"glypican-1-antibody-gpc1-bha17128175","title":"Glypican-1 Antibody \/ GPC1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eGlypican-1 Antibody \/ GPC1 is an antibody targeting \u003cstrong\u003eGPC1\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GPC1.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IHC-P, FACS (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eGlypican-1, also known as GPC1, is a glycosylphosphatidylinositol (GPI)-anchored cell surface proteoglycan that plays a crucial role in various cellular processes, including cell growth, differentiation, and signaling pathways. Recent studies have shown that GPC1 is overexpressed in many types of cancer, including pancreatic, breast, and prostate cancer. This overexpression is thought to contribute to the aggressiveness and metastatic potential of these tumors, making GPC1 a potential target for cancer therapy. One of the key functions of GPC1 in cancer is its ability to interact with growth factors and signaling molecules, such as Wnt and Hedgehog, to promote tumor growth and progression. By blocking the interaction between GPC1 and these molecules, researchers believe they can inhibit the growth of cancer cells and potentially prevent metastasis. In addition to its role in promoting cancer progression, GPC1 has also been found to be a promising biomarker for early detection and prognosis of cancer. Researchers have developed novel diagnostic tools that detect circulating GPC1 levels in the blood, allowing for earlier detection of cancer and more accurate monitoring of treatment response.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eFlow cytometry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry P35052 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/P35052 - Gene search: GPC1 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GPC1 - Ensembl search: GPC1 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GPC1 - PubMed search: GPC1 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GPC1+antibody - Reactome search: GPC1 — Reactome — https:\/\/reactome.org\/content\/query?q=GPC1 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.08 ml","offer_id":53046409331053,"sku":"F55112-0.08ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.4 ml","offer_id":53046468575597,"sku":"F55112-0.4ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e9ac6295-fec8-4d00-bf12-ec4c7b61f87f.jpg?v=1772000495","url":"https:\/\/www.ebiohippo.com\/products\/glypican-1-antibody-gpc1-bha17128175","provider":"BioHippo","version":"1.0","type":"link"}