{"product_id":"gmq-bhb21300150","title":"GMQ","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-(4-methylquinazolin-2-yl)guanidine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e 2-GMQ, 2-Guanidine-4-methylquinazoline\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 716-11-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C10H11N5.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-5 mM.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ASIC1a, ASIC2, ASIC3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e GMQ is an ASIC modulator, ASIC3 opener and also induces an acidic shift of the pH dependence of inactivation of ASIC1a, -1b, -2a, and -31.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e 2-GMQ, 2-Guanidine-4-methylquinazoline\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003e2-guanidine-4-methylquinazoline (GMQ) is a small synthetic nonproton molecule that activates ASIC channels (acid-sensing ion channels). ASICs are proton-gated ion channels which are activated by a decrease in extracellular pH. GMQ is an activator of ASIC3 channels under physiological pH conditions; it induces a window current at pH 7.4 only in ASIC3. Evidence shows that GMQ alters the pH dependence of all ASIC subtypes studied1,2.GMQ contains basic groups that seem to form tight contacts with the carboxyl groups of acidic residues through hydrogen bonds (H-bonds) and electrostatic interactions that lead to the activation of ASIC3. In addition, GMQ contains a guanidinium group and a heterocyclic ring.Additional studies showed that GMQ activates sensory neurons and causes pain-related behaviors in an ASIC3-dependent manner3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249708294509,"sku":"G-130-10MG-1","price":151.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311550652781,"sku":"G-130-25MG-1","price":306.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311550685549,"sku":"G-130-5MG-1","price":85.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311550718317,"sku":"G-130-50MG-1","price":544.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/G-130_gr_UN.gif?v=1778544421","url":"https:\/\/www.ebiohippo.com\/products\/gmq-bhb21300150","provider":"BioHippo","version":"1.0","type":"link"}