{"product_id":"gp6-antibody-glycoprotein-vi-bha17135564","title":"GP6 Antibody \/ Glycoprotein VI","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGP6 Antibody \/ Glycoprotein VI is a anti-GP6 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS) with listed reactivity in Mouse.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GP6\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGP6 antibody detects Glycoprotein VI, a platelet membrane receptor that plays a key role in platelet activation and thrombus formation. GP6 functions as a receptor for collagen and signals through the immunoreceptor tyrosine-based activation motif (ITAM) pathway to promote platelet adhesion and aggregation following vascular injury. The GP6 antibody is widely used in hematology, cardiovascular, and hemostasis research to study platelet activation, coagulation, and thrombotic disease mechanisms.\u003cbr\u003e\u003cbr\u003eGP6 is encoded by the GP6 gene located on human chromosome 19q13.42. The protein is approximately 339 amino acids long and belongs to the immunoglobulin superfamily, featuring two extracellular Ig-like domains, a transmembrane region, and a short cytoplasmic tail that associates with the Fc receptor gamma chain (FcRgamma). This association is necessary for downstream signaling via the SYK tyrosine kinase and phospholipase C gamma 2 cascade.\u003cbr\u003e\u003cbr\u003eThe GP6 antibody detects a 58 kilodalton band by western blot and shows strong membrane localization under flow cytometry and immunofluorescence microscopy. GP6 mediates platelet adhesion to exposed collagen fibers during vascular injury, triggering calcium mobilization, granule secretion, and integrin activation. This sequence of events leads to platelet aggregation and stabilization of the forming clot.\u003cbr\u003e\u003cbr\u003eGenetic deficiencies or polymorphisms in GP6 result in defective platelet-collagen interactions and mild bleeding disorders, while overactivation contributes to thrombotic conditions such as myocardial infarction and stroke. GP6 has also been identified as a therapeutic target for antiplatelet therapy because selective inhibition can prevent thrombosis without affecting normal hemostasis. Additionally, GP6 participates in inflammatory responses by modulating platelet-leukocyte interactions.\u003cbr\u003e\u003cbr\u003eBecause of its central role in platelet physiology and vascular repair, GP6 provides an essential model for studying thrombosis, hemostasis, and inflammation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GP6 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GP6 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GP6 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GP6 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GP6+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047295443309,"sku":"FY12661","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_da10f833-de7c-4f82-a06c-84d6a53afbe3.jpg?v=1782237026","url":"https:\/\/www.ebiohippo.com\/products\/gp6-antibody-glycoprotein-vi-bha17135564","provider":"BioHippo","version":"1.0","type":"link"}