{"product_id":"gp9-antibody-glycoprotein-9-cd42a-bha17135273","title":"Gp9 Antibody \/ Glycoprotein 9 \/ CD42a","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGp9 Antibody \/ Glycoprotein 9 \/ CD42a is a anti-GP9 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GP9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe Gp9 antibody targets Platelet glycoprotein IX, a membrane glycoprotein encoded by the GP9 gene and an essential component of the platelet glycoprotein Ib-IX-V receptor complex. This complex mediates platelet adhesion to subendothelial von Willebrand factor (vWF) following vascular injury, initiating platelet activation and thrombus formation. Platelet glycoprotein IX, together with glycoproteins Ibalpha, Ibbeta, and V, forms the primary receptor responsible for platelet tethering under high shear conditions. The Gp9 antibody provides a vital tool for studying platelet adhesion mechanisms, receptor assembly, and bleeding disorders associated with GPIb-IX-V dysfunction.\u003cbr\u003e\u003cbr\u003ePlatelet glycoprotein IX is a small single-pass transmembrane protein that stabilizes the larger GPIbalpha subunit and ensures correct receptor complex formation. Mutations in the GP9 gene cause Bernard–Soulier syndrome, a rare autosomal recessive bleeding disorder characterized by macrothrombocytopenia and defective platelet adhesion. The Gp9 antibody is essential for diagnosing and researching this condition, as it allows detection of protein expression and complex assembly defects in patient samples and experimental models.\u003cbr\u003e\u003cbr\u003eIn normal hemostasis, GPIb-IX-V engagement with von Willebrand factor triggers intracellular signaling events that activate integrins and promote platelet aggregation. The Gp9 antibody supports studies that dissect these pathways, clarifying how alterations in complex composition affect receptor function. In addition to its hemostatic role, Platelet glycoprotein IX contributes to thrombo-inflammatory responses, vascular repair, and platelet-leukocyte interactions. Using the Gp9 antibody, researchers can quantify expression and localization on the platelet surface and explore its involvement in inflammation and cardiovascular disease.\u003cbr\u003e\u003cbr\u003eThe Gp9 antibody performs effectively in flow cytometry, western blotting, and immunofluorescence. It provides clear detection of Platelet glycoprotein IX in platelets, megakaryocytes, and hematopoietic progenitors. Studies employing this antibody help define the molecular architecture of the GPIb-IX-V complex and its contribution to platelet activation signaling. By facilitating these analyses, the Gp9 antibody aids both basic research and clinical evaluation of platelet receptor disorders.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GP9 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GP9 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GP9 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GP9 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GP9+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047285481837,"sku":"FY12370","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0f7595fb-f46a-4b39-aae5-90aa44657a1b.jpg?v=1782236988","url":"https:\/\/www.ebiohippo.com\/products\/gp9-antibody-glycoprotein-9-cd42a-bha17135273","provider":"BioHippo","version":"1.0","type":"link"}