{"product_id":"grp94-antibody-bha11900041","title":"GRP94 Antibody","description":"\u003cp\u003eGRP94 (also known as gp96) is a constitutively expressed ER-resident chaperone and a member of the HSP90 family. It is upregulated in response to cellular stressors such as heat shock, oxidative damage, and glucose deprivation—conditions frequently observed in neurodegenerative diseases.\u003c\/p\u003e\n\n\u003cp\u003eFunctionally, GRP94 supports protein translocation, folding, and quality control within the ER. It also plays a key role in immune regulation by facilitating antigen presentation through the MHC class I pathway, linking ER stress to immune responses.\u003c\/p\u003e\n\n\u003cp\u003eIn the nervous system, GRP94 contributes to proteostasis and immune surveillance, both of which are disrupted in diseases like Alzheimer’s and Parkinson’s. Structurally, GRP94 forms homodimers and contains a KDEL sequence that ensures ER retention. Despite its homology with cytosolic HSP90, GRP94 exhibits distinct ATP-binding and hydrolysis characteristics, making it a unique therapeutic target.\u003c\/p\u003e\n\n\u003cp\u003eIts dual role in stress adaptation and immune signaling positions GRP94 as a valuable biomarker and potential intervention point in neurodegenerative disease research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"200 ug \/ Unconjugated","offer_id":53040786604397,"sku":"SMC-105B","price":301.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 390","offer_id":53040798630253,"sku":"SMC-105B-A390","price":405.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 488","offer_id":53040798663021,"sku":"SMC-105B-A488","price":402.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 594","offer_id":53040798695789,"sku":"SMC-105B-A594","price":402.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ APC","offer_id":53040798728557,"sku":"SMC-105B-APC","price":401.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ BI","offer_id":53040798761325,"sku":"SMC-105B-BI","price":392.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ FITC","offer_id":53040798794093,"sku":"SMC-105B-FITC","price":384.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ HRP","offer_id":53040798826861,"sku":"SMC-105B-HRP","price":377.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ PCP","offer_id":53040798859629,"sku":"SMC-105B-PCP","price":401.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ RPE","offer_id":53040798892397,"sku":"SMC-105B-RPE","price":394.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040798925165,"sku":"SMC-105S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-105_GRP94_Antibody_9G10_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png?v=1771832126","url":"https:\/\/www.ebiohippo.com\/products\/grp94-antibody-bha11900041","provider":"BioHippo","version":"1.0","type":"link"}