{"product_id":"gstm2-antibody-glutathione-s-transferase-mu-2-bha17135763","title":"GSTM2 Antibody \/ Glutathione S-transferase Mu 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGSTM2 Antibody \/ Glutathione S-transferase Mu 2 is a anti-GSTM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GSTM2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGSTM2 antibody detects Glutathione S-transferase Mu 2, a detoxification enzyme that catalyzes the conjugation of glutathione to electrophilic compounds, protecting cells from oxidative damage and xenobiotic stress. Encoded by the GSTM2 gene on chromosome 1p13.3, this enzyme belongs to the mu class of cytosolic glutathione S-transferases (GSTs) and plays a critical role in the metabolism of carcinogens, environmental toxins, and therapeutic drugs. GSTM2 is particularly abundant in liver, kidney, and lung tissues, where it contributes to phase II detoxification.\u003cbr\u003e\u003cbr\u003eStructurally, GSTM2 forms homodimers, each monomer containing an N-terminal glutathione-binding site (G-site) and a C-terminal hydrophobic substrate-binding site (H-site). This configuration enables GSTM2 to catalyze the conjugation of reduced glutathione (GSH) to electrophilic substrates, rendering them more water-soluble for excretion. GSTM2 also exhibits peroxidase activity, neutralizing reactive oxygen species and maintaining cellular redox balance.\u003cbr\u003e\u003cbr\u003eThe GSTM2 antibody is widely used in toxicology, pharmacology, and metabolic research to study oxidative stress responses, detoxification pathways, and enzyme induction mechanisms. Western blot analysis identifies a 26 kilodalton band corresponding to GSTM2, while immunohistochemistry reveals strong cytoplasmic staining in hepatocytes and renal tubular cells. This antibody supports investigations into tissue-specific detoxification and metabolic adaptation to stress and xenobiotics.\u003cbr\u003e\u003cbr\u003eGenetic polymorphisms in GSTM2 and related GST genes influence susceptibility to environmental toxins, carcinogens, and drug-induced injury. Reduced expression or functional loss of GSTM2 increases oxidative damage and contributes to disorders such as asthma, cancer, and neurodegenerative disease. Conversely, elevated expression is associated with chemoresistance and altered drug metabolism in tumor cells. The GSTM2 antibody provides a reliable tool for quantifying enzyme expression and understanding its contribution to cellular defense systems.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GSTM2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GSTM2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GSTM2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GSTM2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GSTM2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047304290669,"sku":"FY12861","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_ec93dd3c-0084-4cf0-be0f-e6f2578c2b47.jpg?v=1782237050","url":"https:\/\/www.ebiohippo.com\/products\/gstm2-antibody-glutathione-s-transferase-mu-2-bha17135763","provider":"BioHippo","version":"1.0","type":"link"}