{"product_id":"gstm2-antibody-glutathione-s-transferase-mu-2-bha17136145","title":"GSTM2 Antibody \/ Glutathione S-transferase Mu 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGSTM2 Antibody \/ Glutathione S-transferase Mu 2 is a anti-GSTM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GSTM2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGSTM2 antibody detects Glutathione S-transferase Mu 2, an enzyme involved in detoxification and cellular defense against oxidative stress. The UniProt recommended name is Glutathione S-transferase Mu 2 (GSTM2). This cytosolic enzyme catalyzes the conjugation of reduced glutathione to a wide variety of electrophilic compounds, promoting their solubility and excretion while protecting macromolecules from oxidative and chemical damage.\u003cbr\u003e\u003cbr\u003eFunctionally, GSTM2 antibody identifies a 218-amino-acid enzyme belonging to the Mu class of the glutathione S-transferase family. GSTM2 participates in phase II detoxification pathways by binding and neutralizing toxic metabolites, drugs, and environmental carcinogens. It exhibits substrate specificity toward lipid peroxidation products, reactive oxygen species intermediates, and xenobiotic compounds. GSTM2 is also involved in modulating signaling pathways such as JNK and MAPK, linking oxidative stress defense to cell survival and apoptosis regulation.\u003cbr\u003e\u003cbr\u003eThe GSTM2 gene is located on chromosome 1p13.3 and is primarily expressed in liver, skeletal muscle, and brain. Its expression levels vary between individuals due to polymorphisms in the GSTM gene cluster, influencing susceptibility to toxins and disease. As a member of the Mu family, GSTM2 functions alongside other isoenzymes (GSTM1-GSTM5) to maintain redox balance and detoxification capacity.\u003cbr\u003e\u003cbr\u003ePathologically, reduced GSTM2 expression or polymorphic variants have been associated with increased risk of cancer, neurodegenerative disease, and drug-induced toxicity. Elevated GSTM2 levels can enhance cellular resistance to chemotherapy and oxidative damage. Research using GSTM2 antibody supports studies in toxicology, pharmacogenomics, and oxidative stress biology.\u003cbr\u003e\u003cbr\u003eGSTM2 antibody is validated for western blotting, immunohistochemistry, and ELISA to detect detoxification enzymes. \u003cbr\u003e\u003cbr\u003eStructurally, Glutathione S-transferase Mu 2 forms a homodimer with each subunit containing a glutathione-binding (G-site) domain and a hydrophobic substrate-binding (H-site). Its tertiary structure supports efficient conjugation reactions and dynamic interaction with glutathione substrates. This antibody enables investigation of GSTM2's function in metabolic detoxification and cellular stress response.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GSTM2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GSTM2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GSTM2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GSTM2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GSTM2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047320019309,"sku":"FY13243","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_9cff7f73-c017-4c0b-b90b-75d8fb612f69.jpg?v=1782237077","url":"https:\/\/www.ebiohippo.com\/products\/gstm2-antibody-glutathione-s-transferase-mu-2-bha17136145","provider":"BioHippo","version":"1.0","type":"link"}