{"product_id":"guinea-pig-immunoglobulin-g-bhp10506064","title":"Guinea pig Immunoglobulin G","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative guinea pig immunoglobulin G (IgG) is purified from pooled normal guinea pig serum and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Immunoglobulin\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eImmunoglobulin G (IgG) is a Y-shaped antibody composed of two heavy and two light chains, with antigen-binding Fab regions and an Fc region that can engage Fc receptors and complement. IgG is central to humoral immunity and is widely used as a reference reagent for immunoassays, Fc biology studies, and antibody engineering research.\u003c\/p\u003e\u003cp\u003eIgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eFc glycosylation and Fc receptor signaling as drivers of antibody effector function and immune modulation.\u003c\/li\u003e \u003cli\u003eAntibody fragmentation and engineering strategies used to dissect antigen binding vs Fc-mediated interactions.\u003c\/li\u003e \u003cli\u003eAssay standardization efforts that use well-defined IgG materials to improve quantitative comparability across platforms.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eCalibration\/controls for immunoassays and secondary antibody workflows where IgG is a common analyte or standard.\u003c\/li\u003e \u003cli\u003eFc receptor and complement engagement studies (conceptual) that separate binding from downstream effector mechanisms.\u003c\/li\u003e \u003cli\u003eBenchmark reagent in antibody purification, formulation, and stability method development.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eGlycosylation patterns on the Fc region can vary by species and source and can influence Fc receptor\/complement interactions.\u003c\/li\u003e \u003cli\u003ePolyclonal IgG preparations represent a mixture of specificities; interpret binding results accordingly.\u003c\/li\u003e \u003cli\u003eFragment formats (Fc\/Fab) change which interactions are possible; align fragment choice to the biology you want to probe.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=immunoglobulin G IgG structure Fc receptor - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=immunoglobulin G IgG structure Fc receptor - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=immunoglobulin G IgG structure Fc receptor%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 g","offer_id":53052978495853,"sku":"CSB-NP001901Gp-1G","price":1250.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53052978528621,"sku":"CSB-NP001901Gp-100MG","price":250.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53052978561389,"sku":"CSB-NP001901Gp-10MG","price":100.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052978594157,"sku":"CSB-NP001901Gp-1MG","price":50.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP001901Gp-SDS.jpg?v=1772166488","url":"https:\/\/www.ebiohippo.com\/products\/guinea-pig-immunoglobulin-g-bhp10506064","provider":"BioHippo","version":"1.0","type":"link"}