{"product_id":"gzmm-antibody-granzyme-m-bha17136085","title":"GZMM Antibody \/ Granzyme M","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eGZMM Antibody \/ Granzyme M is a anti-GZMM Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Immunohistochemistry (IHC) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e GZMM\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eGZMM antibody detects Granzyme M, a serine protease expressed in cytotoxic lymphocytes and natural killer (NK) cells that mediates immune defense through target cell apoptosis. The UniProt recommended name is Granzyme M (GZMM). This enzyme contributes to innate immunity by inducing non-caspase-dependent cell death and by modulating inflammatory cytokine processing.\u003cbr\u003e\u003cbr\u003eFunctionally, GZMM antibody identifies a 262-amino-acid protein localized to cytotoxic granules of NK and CD8+ T cells. Granzyme M is stored in secretory vesicles and released upon immune activation to cleave intracellular substrates in infected or malignant cells. It works synergistically with perforin and other granzymes to initiate rapid target cell lysis.\u003cbr\u003e\u003cbr\u003eThe GZMM gene is located on chromosome 19p13.3 within the granzyme gene cluster and is expressed predominantly in NK cells and cytotoxic T lymphocytes. GZMM contributes to immune surveillance by degrading viral and bacterial proteins and modulating proinflammatory signaling pathways.\u003cbr\u003e\u003cbr\u003ePathologically, elevated GZMM activity has been observed in inflammatory and autoimmune diseases, as well as in cancer immune responses. Deficiency impairs cytotoxic clearance of pathogens and tumor cells. Research using GZMM antibody supports studies in immunology, cytotoxic signaling, and inflammation control.\u003cbr\u003e\u003cbr\u003eGZMM antibody is validated for western blotting, flow cytometry, and immunohistochemistry to detect cytotoxic granule enzymes. \u003cbr\u003e\u003cbr\u003eStructurally, Granzyme M is a trypsin-like serine protease containing the catalytic triad His-Asp-Ser and a substrate-binding pocket that determines cleavage specificity. This antibody aids in examining GZMM's role in cytotoxic defense and immune regulation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=GZMM - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=GZMM - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=GZMM - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/GZMM - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=GZMM+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047314579821,"sku":"FY13183","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_426c9889-3cce-4695-8c49-1eb0bdec20b8.jpg?v=1782237113","url":"https:\/\/www.ebiohippo.com\/products\/gzmm-antibody-granzyme-m-bha17136085","provider":"BioHippo","version":"1.0","type":"link"}