{"product_id":"hcc1937-cell-bhc11101038","title":"HCC1937 cell","description":"HCC1937 is a human breast carcinoma cell line derived from a primary tumor of an adult female. This cell line exhibits several genetic alterations characteristic of aggressive breast cancer phenotypes, including a homozygous mutation in the BRCA1 gene (5382C mutation), which is a notable marker for predisposition to breast cancer. The presence of this mutation aligns with a familial pattern of breast cancer as it is also detected in other family members, indicating a hereditary aspect to the malignancy. Additionally, HCC1937 has an acquired mutation in the TP53 gene coupled with the loss of the wild-type allele, further compounding its tumor suppressor deficiencies.\n\nThe cell line also displays a homozygous deletion of the PTEN gene and exhibits loss of heterozygosity at multiple loci involved in cancer pathogenesis, suggesting a complex genetic background conducive to oncogenic transformation. From a phenotypic perspective, HCC1937 does not express the estrogen receptor (ER) or progesterone receptor (PR), categorizing it as ER-negative and PR-negative, which are typical markers for more aggressive disease courses. Moreover, the cells do not express Her2-neu and p53, but are positive for epithelial glycoprotein 2 (EGP2) and cytokeratin 19, which are indicative of their epithelial origin and malignant nature. The specific marker profile and genetic makeup make HCC1937 a valuable model for studying the molecular mechanisms of breast cancer and testing targeted therapies for similar aggressive breast cancer profiles.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101038\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205006189,"sku":"305064","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HCC1937_20P1_20305064-M_2020x01_2006102022_1920x1920_ce0b89d1-0e44-42a4-8949-25c2bfa3fba5.jpg?v=1769069036","url":"https:\/\/www.ebiohippo.com\/products\/hcc1937-cell-bhc11101038","provider":"BioHippo","version":"1.0","type":"link"}