{"product_id":"hdhd5-antibody-haloacid-dehalogenase-like-hydrolase-domain-containing-5-cecr5-bha17136066","title":"HDHD5 Antibody \/ Haloacid dehalogenase-like hydrolase domain-containing 5 \/ CECR5","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eHDHD5 Antibody \/ Haloacid dehalogenase-like hydrolase domain-containing 5 \/ CECR5 is a anti-HDHD5 Rabbit antibody Recombinant Rabbit Monoclonal clone 29H91 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e HDHD5\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29H91, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eHDHD5 antibody detects Haloacid dehalogenase-like hydrolase domain-containing protein 5, encoded by the HDHD5 gene, also known as CECR5. This protein belongs to the haloacid dehalogenase-like hydrolase (HAD) superfamily of enzymes, which share a conserved domain associated with phosphatase and hydrolase activity. Although less characterized than some other HAD proteins, Haloacid dehalogenase-like hydrolase domain-containing protein 5 is believed to play a role in regulating nucleotides and possibly RNA metabolism. HDHD5 antibody provides researchers with a highly specific reagent for studying the function of this enigmatic protein and its role in cellular physiology.\u003cbr\u003e\u003cbr\u003eThe HAD superfamily includes enzymes that act on a variety of phosphorylated substrates, ranging from sugars to nucleotides. Research using HDHD5 antibody has revealed that Haloacid dehalogenase-like hydrolase domain-containing protein 5 contains the signature catalytic motifs typical of HAD enzymes, suggesting conserved catalytic potential. Structural studies indicate that it adopts the canonical HAD fold, characterized by a Rossmann-like core and conserved aspartate residues required for catalytic activity. These features strongly suggest that HDHD5 has enzymatic activity related to phosphatase or hydrolase function, though the precise substrate remains under investigation.\u003cbr\u003e\u003cbr\u003eGenetic studies have linked HDHD5 to the Cat Eye syndrome critical region on chromosome 22, where the CECR5 gene is located. Research using HDHD5 antibody has suggested that altered expression of this protein may contribute to phenotypic features of this syndrome, which is characterized by congenital anomalies involving the eyes, heart, and skeletal system. Although the exact contribution of Haloacid dehalogenase-like hydrolase domain-containing protein 5 to Cat Eye syndrome remains unclear, its chromosomal location and potential enzymatic activity make it a protein of strong biomedical interest.\u003cbr\u003e\u003cbr\u003eIn addition to developmental disorders, emerging evidence suggests that HDHD5 may play roles in RNA regulation and cellular stress responses. Studies with HDHD5 antibody have demonstrated that the protein is expressed in multiple tissues, with particularly high expression in metabolically active organs. This distribution pattern supports a potential role in nucleotide metabolism or signaling. Because many HAD superfamily members regulate metabolic flux, Haloacid dehalogenase-like hydrolase domain-containing protein 5 may influence pathways tied to energy balance and gene expression control.\u003cbr\u003e\u003cbr\u003eHDHD5 antibody is a versatile reagent applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms protein size and expression across tissues, immunohistochemistry highlights tissue-specific localization, and immunofluorescence reveals its subcellular distribution, which appears to be both cytoplasmic and nuclear. These applications make HDHD5 antibody valuable for investigating its role in metabolism, signaling, and development.\u003cbr\u003e\u003cbr\u003eFunctional studies with HDHD5 antibody are beginning to clarify its interaction network. Evidence suggests that Haloacid dehalogenase-like hydrolase domain-containing protein 5 may interact with RNA binding proteins or nucleotide processing enzymes, supporting a potential function in RNA maturation or degradation. Its presence in both cytoplasmic and nuclear compartments further suggests a dual role in metabolic and genetic regulation. These observations position HDHD5 as an emerging regulator in pathways not yet fully defined but of significant biomedical importance.\u003cbr\u003e\u003cbr\u003eBy supplying validated HDHD5 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=HDHD5 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HDHD5 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=HDHD5 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/HDHD5 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HDHD5+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047314088301,"sku":"FY13164","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_bb7f2393-4bf2-4ab0-b2fc-dad3ab3b4abd.jpg?v=1772019400","url":"https:\/\/www.ebiohippo.com\/products\/hdhd5-antibody-haloacid-dehalogenase-like-hydrolase-domain-containing-5-cecr5-bha17136066","provider":"BioHippo","version":"1.0","type":"link"}