{"product_id":"hek293-ctla4-cell-bhc11101497","title":"HEK293-CTLA4 cell","description":"Disclaimer: The prices displayed for cell lines are exclusively for not-for-profit customers. If you represent a commercial entity, please contact us for alternative pricing.The HEK293-CTLA4 cell line is a stable recombinant HEK293 cell line engineered to express the CTLA4 receptor at a medium-low level, approximately 4,000 molecules per cell. This cell line was developed using inscreenex's landing pad technology, ensuring precise and reproducible integration of the CTLA4 gene at a specific, pre-validated genomic locus. CTLA4, also known as CD152, is an immune checkpoint protein that plays a crucial role in regulating T-cell activation. By competing with the stimulatory receptor CD28 for binding to B7 molecules (CD80 and CD86) on antigen-presenting cells, CTLA4 downregulates immune responses, thus maintaining self-tolerance and preventing autoimmunity. CTLA4 is a key target in cancer immunotherapy, particularly for drugs like ipilimumab, which aim to enhance anti-tumor immunity by blocking this checkpoint and activating T cells.The expression of CTLA4 in this cell line was confirmed using flow cytometry with a target-specific antibody, ensuring reliable and consistent receptor density across the cell population.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101497\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950205661549,"sku":"305423","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/hek293-hd_1920x1920_3abc4741-6c5c-4661-8cae-bf2958ba2cb3.jpg?v=1769069043","url":"https:\/\/www.ebiohippo.com\/products\/hek293-ctla4-cell-bhc11101497","provider":"BioHippo","version":"1.0","type":"link"}