{"product_id":"hexanoyl-coenzyme-a-free-acid-bhb21200023","title":"Hexanoyl Coenzyme A, Free acid","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eHexanoyl Coenzyme A, Free acid is a biochemical supplied by Coenza for use in enzymology and metabolic research. Available as Lyophilized powder, purity ≥ 95%, suitable for in vitro assays and pathway studies.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAlso known as:\u003c\/em\u003e Hexanoyl-CoA, Caproyl coenzyme A.\u003c\/p\u003e\n\u003ch2\u003eKey Elements and Design Rationale\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormula \/ MW \/ Purity:\u003c\/strong\u003e C27H46N7O17P3S; 865.68 g\/mol; ≥ 95%. The Free Acid form provides enhanced aqueous stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm \/ Solubility:\u003c\/strong\u003e Lyophilized powder; Soluble in water.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynonyms:\u003c\/strong\u003e Hexanoyl-CoA, Caproyl coenzyme A.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrigin:\u003c\/strong\u003e Biosynthetic synthesis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eBiological Background\u003c\/h2\u003e\n\u003cp\u003eHexanoyl coenzyme A (hexanoyl-CoA) is a medium-chain fatty acyl-CoA that serves as a preferred substrate for ghrelin O-acyltransferase (GOAT) in enzyme assays, outperforming octanoyl-CoA. GOAT, the enzyme responsible for the acylation of ghrelin, exhibits a higher catalytic efficiency with hexanoyl-CoA, which enhances ghrelin's biological activity in regulating appetite and energy balance. Hexanoyl-CoA acts as a biosynthetic precursor to olivetolic acid, a key intermediate in the production of phytocannabinoids such as cannabigerolic acid (CBGA). This makes hexanoyl-CoA a functionally important molecule in both mammalian metabolism and plant secondary metabolite biosynthesis (Yang et al., 2016; Gagne et al., 2012).\u003c\/p\u003e\n\u003ch2\u003eResearch Relevance and Current Trends\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAcyl-CoA metabolism increasingly linked to histone acylation marks and epigenetic regulation in cancer and metabolic disease research.\u003c\/li\u003e\n\u003cli\u003eGrowing interest in short-chain fatty acid CoA thioesters as mediators of gut microbiome–host metabolic crosstalk.\u003c\/li\u003e\n\u003cli\u003eCoA-dependent enzymes investigated as drug targets in infectious disease and neurometabolic disorder research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon Research Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eEnzyme kinetics assays — direct substrate for acyltransferases, thiolases, and dehydrogenases.\u003c\/li\u003e\n\u003cli\u003eMetabolic flux analysis — isotope-labeled variants available for stable-isotope tracing.\u003c\/li\u003e\n\u003cli\u003eIn vitro pathway reconstitution for fatty acid β-oxidation, TCA cycle, or polyketide biosynthesis.\u003c\/li\u003e\n\u003cli\u003eBiochemical characterization of CoA-binding proteins by activity assays or binding measurements.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eNotes for Experimental Interpretation\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCoA thioesters hydrolyze at neutral–alkaline pH; prepare working solutions fresh and keep on ice.\u003c\/li\u003e\n\u003cli\u003eDifferent salt forms share the same core structure — normalize concentrations using the free-acid MW when comparing across forms.\u003c\/li\u003e\n\u003cli\u003eThiol oxidation may occur upon air exposure; use under inert atmosphere or with reducing agents where appropriate.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Coenza","offers":[{"title":"10 mg","offer_id":53249727070573,"sku":"A-28-10MG","price":556.9,"currency_code":"USD","in_stock":true},{"title":"25 mg","offer_id":53249731854701,"sku":"A-28-25MG","price":988.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/53dbfa_670bcc38756049b4a7b38c8d1bbdb48a_mv2.png?v=1776855580","url":"https:\/\/www.ebiohippo.com\/products\/hexanoyl-coenzyme-a-free-acid-bhb21200023","provider":"BioHippo","version":"1.0","type":"link"}