{"product_id":"hpgd-antibody-15-hydroxyprostaglandin-dehydrogenase-bha17136290","title":"HPGD Antibody \/ 15-hydroxyprostaglandin dehydrogenase","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eHPGD Antibody \/ 15-hydroxyprostaglandin dehydrogenase is a anti-HPGD Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, Nucleus.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e HPGD\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eHPGD antibody detects 15-hydroxyprostaglandin dehydrogenase, an NAD+-dependent oxidoreductase encoded by the HPGD gene located on chromosome 4q34.1. HPGD serves as the key enzyme responsible for the biological inactivation of prostaglandins by catalyzing the oxidation of the 15(S)-hydroxyl group to a keto group. Through this reaction, HPGD regulates local prostaglandin levels, modulating inflammation, vasodilation, and cell proliferation. It is expressed in lung, colon, placenta, and kidney, acting as a crucial counter-regulator of prostaglandin synthesis pathways mediated by cyclooxygenases (COX-1 and COX-2).\u003cbr\u003e\u003cbr\u003eStructurally, HPGD is a cytosolic enzyme of approximately 29 kDa that functions as a homodimer. It belongs to the short-chain dehydrogenase\/reductase (SDR) family and requires NAD+ as a cofactor for catalytic activity. Its active site includes conserved serine, tyrosine, and lysine residues essential for proton transfer and substrate oxidation. Co-localization studies show HPGD present in cytoplasmic and perinuclear regions of epithelial cells and macrophages, consistent with its role in eicosanoid metabolism.\u003cbr\u003e\u003cbr\u003eFunctionally, HPGD controls the turnover of bioactive prostaglandins such as PGE2, PGF2alpha, and PGD2. By inactivating these lipid mediators, it dampens inflammatory signaling, cell migration, and angiogenesis. HPGD also participates in the prostaglandin catabolic pathway linked to tumor suppression, as loss of HPGD function often leads to prostaglandin accumulation and oncogenic signaling. The enzyme interacts with various prostaglandin transporters and metabolic enzymes, including SLCO2A1 and AKR1C family members, to coordinate prostaglandin clearance.\u003cbr\u003e\u003cbr\u003eDeficiency or silencing of HPGD is associated with several diseases, including colon and lung cancer, endometrial carcinoma, and familial digital clubbing caused by elevated prostaglandin E2. Overexpression, conversely, suppresses tumor growth by limiting COX-2-driven signaling. Pathway involvement includes prostaglandin degradation, arachidonic acid metabolism, and inflammation resolution. During development, HPGD contributes to vascular remodeling and placental differentiation.\u003cbr\u003e\u003cbr\u003eThe HPGD antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=HPGD - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HPGD - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=HPGD - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/HPGD - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HPGD+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047324705133,"sku":"FY13389","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_0f09e07f-28e6-41d1-894e-185d66722a7f.jpg?v=1782237117","url":"https:\/\/www.ebiohippo.com\/products\/hpgd-antibody-15-hydroxyprostaglandin-dehydrogenase-bha17136290","provider":"BioHippo","version":"1.0","type":"link"}