{"product_id":"hsc70-hsp73-antibody-bha11900720","title":"HSC70 (HSP73) Antibody","description":"\u003cp\u003eThe HSP70 family comprises highly conserved, heat-inducible 70-kDa proteins that play a pivotal role in maintaining cellular proteostasis, particularly under stress conditions. Encoded by a multigene family in most eukaryotes, HSP70 proteins are ubiquitously distributed across cellular compartments—including the cytosol, nucleus, mitochondria, endoplasmic reticulum, and chloroplasts—and are also present in prokaryotes. Their evolutionary conservation, with over 50% sequence identity, underscores their essential biological functions.\u003c\/p\u003e\n\n\u003cp\u003eHSP70 proteins exhibit high-affinity ATP binding and possess ATPase activity, which is enhanced upon interaction with unfolded proteins and synthetic peptides. Structurally, the N-terminal domain mediates ATP binding, while the C-terminal domain governs substrate interaction. This dual-domain architecture enables HSP70s to act as molecular chaperones, facilitating protein folding, preventing aggregation, and promoting recovery from proteotoxic stress.\u003c\/p\u003e\n\n\u003cp\u003eIn the context of neurodegenerative diseases, inducible HSP70 (HSP72) and its constitutively expressed counterpart HSC70 are of particular interest. Following cellular stress, such as heat shock, HSP72 is rapidly upregulated and forms ATP-dependent complexes with HSC70. This interaction is critical for restoring centrosomal integrity and function—processes often disrupted in neurodegenerative pathologies like Alzheimer’s and Parkinson’s disease.\u003c\/p\u003e\n\n\u003cp\u003eGiven their central role in protein quality control and cellular resilience, HSP70 proteins are emerging as promising therapeutic targets in neuroscience and neurodegeneration research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"200 ug \/ Unconjugated","offer_id":53040786211181,"sku":"SMC-151B","price":370.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 390","offer_id":53040806691181,"sku":"SMC-151B-A390","price":474.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 488","offer_id":53040806723949,"sku":"SMC-151B-A488","price":471.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 594","offer_id":53040806756717,"sku":"SMC-151B-A594","price":471.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ APC","offer_id":53040806789485,"sku":"SMC-151B-APC","price":470.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ BI","offer_id":53040806822253,"sku":"SMC-151B-BI","price":461.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ FITC","offer_id":53040806855021,"sku":"SMC-151B-FITC","price":453.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ HRP","offer_id":53040806887789,"sku":"SMC-151B-HRP","price":447.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ PCP","offer_id":53040806920557,"sku":"SMC-151B-PCP","price":470.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ RPE","offer_id":53040806953325,"sku":"SMC-151B-RPE","price":463.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040806986093,"sku":"SMC-151S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-151_Hsc70-Hsp73_Antibody_1F2-H5_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png?v=1771832139","url":"https:\/\/www.ebiohippo.com\/products\/hsc70-hsp73-antibody-bha11900720","provider":"BioHippo","version":"1.0","type":"link"}