{"product_id":"hsd17b13-antibody-dhb13-7-beta-hydroxysteroid-dehydrogenase-13-bha17128121","title":"HSD17B13 Antibody \/ DHB13 \/ 7-beta hydroxysteroid dehydrogenase 13","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eHSD17B13 Antibody \/ DHB13 \/ 7-beta hydroxysteroid dehydrogenase 13 is an antibody targeting \u003cstrong\u003eDHB13\u003c\/strong\u003e, raised in \u003cstrong\u003eRabbit\u003c\/strong\u003e for protein detection and localization studies where these specifications are required.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e DHB13 (reported localization: Cytoplasm).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eAntibody identity:\u003c\/strong\u003e Polyclonal (rabbit origin); Rabbit Ig.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eConjugate\/label:\u003c\/strong\u003e Unconjugated (affects detection chemistry and multiplex compatibility).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Antigen affinity purified.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eListed applications:\u003c\/strong\u003e WB, IHC-P (refer to on-page specifications for application-specific guidance).\u003c\/li\u003e \u003c\/ul\u003e  \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eHSD17B13 protein is an enzyme that plays a key role in the metabolism of steroids and lipids in the body. Specifically, it is involved in the conversion of various hormones and fatty acids, making it a critical player in maintaining metabolic homeostasis. Additionally, studies have shown that mutations or dysregulation of the HSD17B13 gene can lead to impaired lipid metabolism and contribute to the development of liver diseases such as non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease. HSD17B13 protein is a potential therapeutic target for liver diseases.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eComparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).\u003c\/li\u003e \u003cli\u003eSubcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.\u003c\/li\u003e \u003cli\u003eIntegration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eWestern blotting: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003cli\u003eImmunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative\/positive controls for interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eInterpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eIsoforms and PTMs:\u003c\/strong\u003e many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands\/signals accordingly.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eEpitope context:\u003c\/strong\u003e binding can depend on protein conformation and sample processing; region information in the title\/immunogen can help anticipate what may be detected.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eSpecies differences:\u003c\/strong\u003e predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eControl concepts:\u003c\/strong\u003e include negative controls (no-primary\/isotype), and where possible genetic controls (KO\/KD) or independent antibodies to strengthen conclusions.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProtKB entry Q7Z5P4 — UniProt — https:\/\/www.uniprot.org\/uniprotkb\/Q7Z5P4 - Gene search: DHB13 — NCBI Gene — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=DHB13 - Ensembl search: DHB13 — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=DHB13 - PubMed search: DHB13 antibody — PubMed — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=DHB13+antibody - Reactome search: DHB13 — Reactome — https:\/\/reactome.org\/content\/query?q=DHB13 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.05 ml","offer_id":53046408872301,"sku":"F55058-0.05ML","price":205.0,"currency_code":"USD","in_stock":true},{"title":"In 1X PBS, pH 7.4, with 0.09% sodium azide \/ 0.2 ml","offer_id":53046470050157,"sku":"F55058-0.2ML","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fd1b078a-628e-4b33-a61c-42713b146dad.jpg?v=1772000493","url":"https:\/\/www.ebiohippo.com\/products\/hsd17b13-antibody-dhb13-7-beta-hydroxysteroid-dehydrogenase-13-bha17128121","provider":"BioHippo","version":"1.0","type":"link"}