{"product_id":"hsp22-antibody-bha11907120","title":"HSP22 Antibody","description":"\u003cp\u003eHSP22, also known as HSPB8, is a 196-amino acid member of the small heat shock protein (sHSP) superfamily, closely related to HSP27. While predominantly expressed in skeletal muscle, heart, and placenta, HSP22 is increasingly recognized for its critical role in neuronal health and neurodegenerative disease.\u003c\/p\u003e\n\n\u003cp\u003eFunctioning as a monomer, HSP22 exhibits temperature-dependent chaperone activity and interacts with other sHSPs, including HSPB1 (HSP27). It preferentially binds phosphorylated forms of HSP27, suggesting a role in stress-adaptive signaling. HSP22 contains distinct N- and C-terminal domains that mediate interactions with various protein partners, enabling it to participate in essential cellular processes such as protein quality control, apoptosis, and macroautophagy.\u003c\/p\u003e\n\n\u003cp\u003eImportantly, HSP22 has emerged as a key player in neurodegenerative disease mechanisms. Mutations in the HSPB8 gene are linked to inherited peripheral neuropathies, including distal hereditary motor neuropathy type IIA (dHMNIIA) and Charcot-Marie-Tooth disease type 2L (CMT2L). These disorders are characterized by axonal degeneration and impaired motor function, underscoring HSP22’s role in maintaining neuronal integrity.\u003c\/p\u003e\n\n\u003cp\u003eBy promoting the clearance of misfolded proteins and supporting autophagic pathways, HSP22 contributes to cellular resilience in the face of proteotoxic stress—a hallmark of neurodegenerative conditions such as ALS and Alzheimer’s disease. Its dual role in chaperone activity and neuroprotection positions HSP22 as a promising target for therapeutic intervention in neuroscience.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 uL \/ Unconjugated","offer_id":53040793944429,"sku":"SPC-181D","price":282.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ ATTO 390","offer_id":53040872391021,"sku":"SPC-181D-A390","price":337.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ ATTO 488","offer_id":53040872423789,"sku":"SPC-181D-A488","price":336.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ ATTO 594","offer_id":53040872456557,"sku":"SPC-181D-A594","price":336.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ APC","offer_id":53040872489325,"sku":"SPC-181D-APC","price":335.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ BI","offer_id":53040872522093,"sku":"SPC-181D-BI","price":332.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ FITC","offer_id":53040872554861,"sku":"SPC-181D-FITC","price":326.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ HRP","offer_id":53040872587629,"sku":"SPC-181D-HRP","price":322.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ PCP","offer_id":53040872620397,"sku":"SPC-181D-PCP","price":335.0,"currency_code":"USD","in_stock":true},{"title":"100 uL \/ RPE","offer_id":53040872653165,"sku":"SPC-181D-RPE","price":333.0,"currency_code":"USD","in_stock":true},{"title":"12 uL \/ Unconjugated","offer_id":53040872685933,"sku":"SPC-181S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-181_HSP22_Antibody_ICC-IF_Human_HaCaT-cells_3.png?v=1771832153","url":"https:\/\/www.ebiohippo.com\/products\/hsp22-antibody-bha11907120","provider":"BioHippo","version":"1.0","type":"link"}