{"product_id":"hsp25-hsp27-antibody-bha11900221","title":"HSP25\/HSP27 Antibody","description":"\u003cp\u003eHSP25 (mouse) and its human homolog HSP27 are members of the small heat shock protein (sHSP) family, characterized by a conserved α-crystallin domain and a variable N-terminal region essential for oligomerization. These proteins form dynamic oligomers ranging from dimers to large multimers (8–40 monomers), with chaperone activity closely tied to their oligomeric state—larger assemblies exhibit potent anti-aggregation functions, while dimers are inactive.\u003c\/p\u003e\n\n\u003cp\u003eHSP27 is predominantly cytoplasmic under basal conditions but rapidly translocates to the nucleus in response to cellular stress, where it may stabilize nuclear structures and DNA. It is also rapidly phosphorylated in response to various stimuli, linking it to second messenger signaling pathways. Functionally, HSP27 acts as an ATP-independent molecular chaperone, preventing protein aggregation and stabilizing partially unfolded proteins, often in coordination with the HSP70 complex.\u003c\/p\u003e\n\n\u003cp\u003eIn the nervous system, HSP27 plays a critical role in protecting neurons from proteotoxic stress, apoptosis, and oxidative damage—key features of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. It inhibits apoptotic signaling by blocking the cytochrome c\/Apaf-1\/procaspase-9 complex and may also influence cytoskeletal dynamics through interactions with actin and myosin.\u003c\/p\u003e\n\n\u003cp\u003eUpregulation of HSP27 correlates with increased phosphorylation and oligomer formation, suggesting a role in stress adaptation, cell differentiation, and potentially growth arrest. These properties make HSP27 a compelling target for therapeutic strategies aimed at enhancing neuronal resilience in neurodegenerative disease.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040787259757,"sku":"SMC-114D","price":285.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/  ATTO 390","offer_id":53040843063661,"sku":"SMC-114D-A390","price":340.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040843096429,"sku":"SMC-114D-A488","price":339.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040843129197,"sku":"SMC-114D-A594","price":339.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040843161965,"sku":"SMC-114D-APC","price":338.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040843194733,"sku":"SMC-114D-BI","price":335.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040843227501,"sku":"SMC-114D-FITC","price":329.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040843260269,"sku":"SMC-114D-HRP","price":325.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040843293037,"sku":"SMC-114D-PCP","price":338.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040843325805,"sku":"SMC-114D-RPE","price":336.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040843358573,"sku":"SMC-114S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-114_Hsp27_Antibody_8A7_IP_Rat_embryo-somites_1.png?v=1771832139","url":"https:\/\/www.ebiohippo.com\/products\/hsp25-hsp27-antibody-bha11900221","provider":"BioHippo","version":"1.0","type":"link"}