{"product_id":"hsp27-antibody-bha11906324","title":"HSP27 Antibody","description":"\u003cp\u003eHSP27, a member of the small heat shock protein (sHSP) family, is an abundant and ubiquitously expressed molecular chaperone found in both normal and cancerous human cells. Structurally, HSP27 features a conserved α-crystallin domain at the C-terminus and a less conserved N-terminal WD\/EPF domain, which is essential for forming high-molecular-weight oligomers. These oligomers, composed of 8–40 monomers, are critical for HSP27’s chaperone activity—larger assemblies exhibit strong anti-aggregation properties, while dimers are inactive.\u003c\/p\u003e\n\n\u003cp\u003eUnder non-stress conditions, HSP27 resides in the cytoplasm but rapidly translocates to the nucleus in response to cellular stress, where it may help stabilize DNA and nuclear membranes. Functioning as an ATP-independent chaperone, HSP27 prevents protein aggregation and stabilizes partially unfolded proteins, facilitating their refolding via the HSP70 complex.\u003c\/p\u003e\n\n\u003cp\u003eIn neuroscience, HSP27 is increasingly recognized for its role in protecting neurons from proteotoxic stress, oxidative damage, and apoptosis—key features of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. It inhibits apoptotic signaling by blocking the cytochrome c\/Apaf-1\/procaspase-9 complex and may also influence cytoskeletal dynamics through interactions with actin and myosin.\u003c\/p\u003e\n\n\u003cp\u003eHSP27 expression is tightly regulated by phosphorylation, which promotes the formation of large, active oligomers. Its involvement in stress response, apoptosis inhibition, and cell differentiation highlights its therapeutic potential in neurodegenerative disease research and intervention.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"200 ug \/ Unconjugated","offer_id":53040792535405,"sku":"SPC-106B","price":281.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 390","offer_id":53040862396781,"sku":"SPC-106B-A390","price":385.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 488","offer_id":53040862429549,"sku":"SPC-106B-A488","price":381.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 594","offer_id":53040862462317,"sku":"SPC-106B-A594","price":381.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ APC","offer_id":53040862495085,"sku":"SPC-106B-APC","price":380.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ BI","offer_id":53040862527853,"sku":"SPC-106B-BI","price":370.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ FITC","offer_id":53040862560621,"sku":"SPC-106B-FITC","price":362.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ HRP","offer_id":53040862593389,"sku":"SPC-106B-HRP","price":356.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ PCP","offer_id":53040862626157,"sku":"SPC-106B-PCP","price":380.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ RPE","offer_id":53040862658925,"sku":"SPC-106B-RPE","price":373.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040862691693,"sku":"SPC-106S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SPC-106_Hsp27_Antibody_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png?v=1771832151","url":"https:\/\/www.ebiohippo.com\/products\/hsp27-antibody-bha11906324","provider":"BioHippo","version":"1.0","type":"link"}