{"product_id":"hsp47-antibody-bha11901624","title":"HSP47 Antibody","description":"\u003cp\u003eHSP47, also known as SERPINH1, is a unique member of the serine protease inhibitor (serpin) superfamily that functions as a collagen-specific molecular chaperone. Localized in the endoplasmic reticulum, HSP47 plays a critical role in the intracellular folding, assembly, and secretion of procollagens—particularly type I collagen, a key structural component in tissue repair and remodeling.\u003c\/p\u003e\n\n\u003cp\u003eUnlike other heat shock proteins, HSP47 binds a single substrate: collagen. This specificity makes it a promising biomarker and therapeutic target in fibrotic diseases, where its expression is markedly elevated around fibrotic lesions. Recent studies suggest that modulating HSP47 activity could support cell-based therapies aimed at halting or reversing fibrosis progression.\u003c\/p\u003e\n\n\u003cp\u003eIn the context of neuroscience, HSP47 is gaining attention for its role in post-injury tissue remodeling. Type I collagen is essential for scar formation and structural integrity following events such as myocardial infarction or central nervous system injury. HSP47 facilitates the proper positioning of collagen-producing cells and the assembly of collagen fibrils—processes that are also relevant in neurodegenerative conditions involving extracellular matrix dysregulation.\u003c\/p\u003e\n\n\u003cp\u003eGiven its substrate specificity and stress-inducible nature, HSP47 represents a novel intersection between fibrosis, wound healing, and neurodegeneration, with potential as a universal marker and therapeutic target in regenerative medicine.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"200 ug \/ Unconjugated","offer_id":53040787718509,"sku":"SMC-203B","price":370.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 390","offer_id":53040828350829,"sku":"SMC-203B-A390","price":474.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 488","offer_id":53040828383597,"sku":"SMC-203B-A488","price":471.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 594","offer_id":53040828416365,"sku":"SMC-203B-A594","price":471.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ APC","offer_id":53040828449133,"sku":"SMC-203B-APC","price":470.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ BI","offer_id":53040828481901,"sku":"SMC-203B-BI","price":461.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ FITC","offer_id":53040828514669,"sku":"SMC-203B-FITC","price":453.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ HRP","offer_id":53040828547437,"sku":"SMC-203B-HRP","price":447.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ PCP","offer_id":53040828580205,"sku":"SMC-203B-PCP","price":470.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ RPE","offer_id":53040828612973,"sku":"SMC-203B-RPE","price":463.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040828645741,"sku":"SMC-203S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-203_Hsp47_Antibody_1C4-1A6_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png?v=1771832141","url":"https:\/\/www.ebiohippo.com\/products\/hsp47-antibody-bha11901624","provider":"BioHippo","version":"1.0","type":"link"}