{"product_id":"hsp70-antibody-bha11900976","title":"HSP70 Antibody","description":"\u003cp\u003eHSP70 proteins are a highly conserved family of 70-kDa molecular chaperones encoded by a multigene family in most eukaryotes and prokaryotes. Found in nearly all cellular compartments—including the cytosol, nucleus, mitochondria, endoplasmic reticulum, and chloroplasts—HSP70s are constitutively expressed and strongly upregulated in response to cellular stress.\u003c\/p\u003e\n\n\u003cp\u003eThese chaperones play a vital role in protein homeostasis by binding to nascent polypeptides and partially folded or misfolded proteins, preventing aggregation and facilitating proper folding. HSP70s exhibit high-affinity ATP binding and weak ATPase activity, which is stimulated upon interaction with unfolded substrates. ATP hydrolysis triggers conformational changes that regulate substrate binding and release, enabling dynamic cycles of protein folding and refolding.\u003c\/p\u003e\n\n\u003cp\u003eStructurally, the N-terminal domain of HSP70 is responsible for ATP binding, while the C-terminal domain mediates substrate interaction. This modular design allows HSP70s to coordinate with co-chaperones such as HSP40, HIP, HOP, and BAG-1, integrating folding with degradation and transport pathways.\u003c\/p\u003e\n\n\u003cp\u003eIn neurodegenerative disease research, HSP70 is of particular interest due to its ability to counteract protein misfolding and aggregation—hallmarks of disorders like Alzheimer’s, Parkinson’s, and Huntington’s disease. By stabilizing toxic intermediates and promoting their clearance, HSP70 enhances neuronal survival and resilience under proteotoxic stress.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"100 ug \/ Unconjugated","offer_id":53040789881197,"sku":"SMC-164D","price":317.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 390","offer_id":53040806363501,"sku":"SMC-164D-A390","price":372.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 488","offer_id":53040806396269,"sku":"SMC-164D-A488","price":370.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ ATTO 594","offer_id":53040806429037,"sku":"SMC-164D-A594","price":370.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ APC","offer_id":53040806461805,"sku":"SMC-164D-APC","price":369.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ BI","offer_id":53040806494573,"sku":"SMC-164D-BI","price":366.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ FITC","offer_id":53040806527341,"sku":"SMC-164D-FITC","price":361.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ HRP","offer_id":53040806560109,"sku":"SMC-164D-HRP","price":357.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ PCP","offer_id":53040806592877,"sku":"SMC-164D-PCP","price":369.0,"currency_code":"USD","in_stock":true},{"title":"100 ug \/ RPE","offer_id":53040806625645,"sku":"SMC-164D-RPE","price":367.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040806658413,"sku":"SMC-164S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-164-HSP70-Antibody-3A3-ICC-IF-Human-Cervical-Cancer-cell-line-HeLa-40X-Composite-1.png?v=1771832131","url":"https:\/\/www.ebiohippo.com\/products\/hsp70-antibody-bha11900976","provider":"BioHippo","version":"1.0","type":"link"}