{"product_id":"hsp70-hsc70-antibody-bha11900061","title":"HSP70\/HSC70 Antibody","description":"\u003cp\u003eHSP70 proteins are a highly conserved family of 70-kDa molecular chaperones essential for maintaining protein homeostasis across all domains of life. In eukaryotes, HSP70 genes form a multigene family, with isoforms localized to the cytosol, nucleus, mitochondria, endoplasmic reticulum, and chloroplasts. These chaperones are either constitutively expressed (HSC70) or stress-inducible (HSP70), and share over 50% sequence identity across species.\u003c\/p\u003e\n\n\u003cp\u003eFunctionally, HSP70s bind ATP with high affinity and exhibit ATPase activity that is stimulated by interaction with unfolded or misfolded proteins. The N-terminal domain mediates ATP binding, while the C-terminal domain is responsible for substrate recognition. This ATP-driven cycle enables HSP70s to bind and release hydrophobic regions of nascent or damaged proteins, preventing aggregation and facilitating proper folding, transport, and assembly.\u003c\/p\u003e\n\n\u003cp\u003eIn neuroscience, HSP70 and HSC70 are critical for neuronal survival under proteotoxic stress—conditions commonly associated with neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. These chaperones stabilize misfolded proteins, support autophagic clearance, and modulate apoptotic signaling pathways. Their ability to interact with co-chaperones and degradation machinery further enhances their role in maintaining neuronal proteostasis.\u003c\/p\u003e\n\n\u003cp\u003eGiven their central role in stress response and protein quality control, HSP70\/HSC70 are promising therapeutic targets and biomarkers in neurodegeneration research.\u003c\/p\u003e","brand":"StressMarq Biosciences Inc.","offers":[{"title":"200 ug \/ Unconjugated","offer_id":53040786473325,"sku":"SMC-106B","price":352.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 390","offer_id":53040800268653,"sku":"SMC-106B-A390","price":457.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 488","offer_id":53040800301421,"sku":"SMC-106B-A488","price":453.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ ATTO 594","offer_id":53040800334189,"sku":"SMC-106B-A594","price":453.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ APC","offer_id":53040800366957,"sku":"SMC-106B-APC","price":452.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ BI","offer_id":53040800399725,"sku":"SMC-106B-BI","price":444.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ FITC","offer_id":53040800432493,"sku":"SMC-106B-FITC","price":436.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ HRP","offer_id":53040800465261,"sku":"SMC-106B-HRP","price":427.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ PCP","offer_id":53040800498029,"sku":"SMC-106B-PCP","price":452.0,"currency_code":"USD","in_stock":true},{"title":"200 ug \/ RPE","offer_id":53040800530797,"sku":"SMC-106B-RPE","price":446.0,"currency_code":"USD","in_stock":true},{"title":"12 ug \/ Unconjugated","offer_id":53040800563565,"sku":"SMC-106S","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/SMC-106_Hsp70_Antibody_BB70_IHC_Mouse_inflamed-colon_40x_1.png?v=1771832132","url":"https:\/\/www.ebiohippo.com\/products\/hsp70-hsc70-antibody-bha11900061","provider":"BioHippo","version":"1.0","type":"link"}