{"product_id":"htr3e-antibody-5-hydroxytryptamine-receptor-3e-bha17135280","title":"HTR3E Antibody \/ 5-hydroxytryptamine receptor 3E","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eHTR3E Antibody \/ 5-hydroxytryptamine receptor 3E is a anti-HTR3E Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasm, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e HTR3E\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe HTR3E antibody targets 5-hydroxytryptamine receptor 3E, a serotonin receptor subunit encoded by the HTR3E gene. This protein belongs to the ligand-gated ion channel family and contributes to the formation of functional 5-HT3 receptor complexes that mediate fast excitatory neurotransmission in the central and peripheral nervous systems. 5-hydroxytryptamine receptor 3E does not form functional homopentamers by itself but modulates receptor properties when co-assembled with other 5-HT3 subunits such as HTR3A. The HTR3E antibody allows researchers to study this modulatory subunit's expression, localization, and physiological roles in serotonergic signaling.\u003cbr\u003e\u003cbr\u003e5-hydroxytryptamine receptor 3E influences the biophysical and pharmacological characteristics of heteromeric 5-HT3 receptors. Its inclusion in the receptor complex alters ion conductance, ligand sensitivity, and desensitization kinetics. The HTR3E antibody supports detection of this subunit in intestinal epithelium, brainstem, and enteric neurons, where serotonergic signaling regulates motility, secretion, and sensory transmission. Expression in the gastrointestinal tract suggests a potential role in visceral sensory modulation and nausea control.\u003cbr\u003e\u003cbr\u003ePolymorphisms in the HTR3E gene have been linked to irritable bowel syndrome, functional dyspepsia, and other serotonin-related gastrointestinal disorders. The HTR3E antibody facilitates analysis of protein expression in these contexts, helping to clarify the molecular basis of serotonin receptor diversity and disease susceptibility. In the nervous system, 5-hydroxytryptamine receptor 3E expression may fine-tune synaptic activity and contribute to central processing of nausea, anxiety, and emesis. Detection using the HTR3E antibody supports studies on how receptor composition affects neurotransmission and pharmacologic responses to 5-HT3 antagonists used in antiemetic therapy.\u003cbr\u003e\u003cbr\u003eBeyond physiology, aberrant expression of 5-hydroxytryptamine receptor 3E has been observed in some cancers, suggesting roles in tumor cell signaling and proliferation. The HTR3E antibody allows evaluation of receptor expression in tumor tissues and cultured cells, supporting research into serotonin-mediated growth regulation. Functional studies continue to explore how HTR3E variants influence receptor pharmacodynamics and sensitivity to drugs such as ondansetron and granisetron.\u003cbr\u003e\u003cbr\u003eThe HTR3E antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry. It provides clear membrane and cytoplasmic staining consistent with receptor localization.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=HTR3E - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HTR3E - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=HTR3E - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/HTR3E - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HTR3E+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047286038893,"sku":"FY12377","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_f1353133-803c-4f37-8208-7a0750888b38.jpg?v=1782236995","url":"https:\/\/www.ebiohippo.com\/products\/htr3e-antibody-5-hydroxytryptamine-receptor-3e-bha17135280","provider":"BioHippo","version":"1.0","type":"link"}