{"product_id":"htra1-antibody-htra-serine-peptidase-1-bha17135989","title":"HTRA1 Antibody \/ HtrA serine peptidase 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eHTRA1 Antibody \/ HtrA serine peptidase 1 is a anti-HTRA1 Rabbit antibody Recombinant Rabbit Monoclonal clone 31H06 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e HTRA1\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31H06, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eHTRA1 antibody detects HtrA serine peptidase 1, encoded by the HTRA1 gene. This protein is a member of the HtrA family of serine proteases that regulate extracellular matrix remodeling, growth factor signaling, and stress responses. HtrA serine peptidase 1 is secreted and functions as a regulator of transforming growth factor beta signaling by degrading extracellular matrix proteins and growth factors. HTRA1 antibody provides researchers with a valuable reagent to study cell signaling, angiogenesis, and disease mechanisms.\u003cbr\u003e\u003cbr\u003eHtrA serine peptidase 1 has been implicated in cancer, age related macular degeneration, and arthritis. Research with HTRA1 antibody has shown that increased expression suppresses transforming growth factor beta signaling, influencing proliferation and differentiation. In tumors, HTRA1 can act as a tumor suppressor by promoting degradation of pro survival factors, but in other contexts it may enhance invasion by degrading extracellular matrix components. This dual role underscores its complex function in tissue homeostasis and pathology.\u003cbr\u003e\u003cbr\u003eIn ophthalmology, polymorphisms in the HTRA1 gene are strongly associated with risk of age related macular degeneration. Studies with HTRA1 antibody have demonstrated elevated expression in retinal tissues from affected individuals, suggesting a role in disease pathogenesis through dysregulation of extracellular remodeling and angiogenesis. This makes HtrA serine peptidase 1 an important biomarker and potential therapeutic target in retinal disease.\u003cbr\u003e\u003cbr\u003eHTRA1 also contributes to osteoarthritis and inflammatory joint disease. By degrading matrix proteins such as fibronectin and aggrecan, it influences cartilage turnover and inflammation. Research with HTRA1 antibody has confirmed its presence in synovial tissue and joint fluid, where it participates in matrix breakdown. Targeting HTRA1 activity is being investigated as a strategy to slow joint degeneration.\u003cbr\u003e\u003cbr\u003eHTRA1 antibody is applied in western blotting, immunohistochemistry, and ELISA. Western blotting reveals multiple processed forms of the protein, immunohistochemistry shows localization in extracellular and pericellular spaces, and ELISA quantifies soluble levels in fluids. These applications make HTRA1 antibody essential in studies of extracellular proteases and disease.\u003cbr\u003e\u003cbr\u003eBy supplying validated HTRA1 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=HTRA1 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=HTRA1 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=HTRA1 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/HTRA1 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=HTRA1+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047312089453,"sku":"FY13087","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e9121fa4-675c-4c79-abbe-ffe1ab226259.jpg?v=1772019388","url":"https:\/\/www.ebiohippo.com\/products\/htra1-antibody-htra-serine-peptidase-1-bha17135989","provider":"BioHippo","version":"1.0","type":"link"}