{"product_id":"human-5-hydroxyeicosatetraenoic-acid-5-hete-elisa-kit-bhe13703050","title":"Human 5-hydroxyeicosatetraenoic acid (5-HETE) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman 5-hydroxyeicosatetraenoic acid (5-HETE) ELISA Kit has high sensitivity and excellent specificity for detection of Human 5-HETE. No significant cross-reactivity or interference between Human 5-HETE and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003e5-Hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.\u003c\/p\u003e\u003cp\u003e5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes\/macrophages exposed to peroxynitrite. Peroxynitrite elicited the nuclear membrane translocation of 5-LO and enhanced its enzymatic activity via a mechanism sensitive to low concentrations of inhibitors of 5-LO or the 5-LO-activating protein, as well as to genetic depletion of the latter enzyme. Inhibition of 5-LO activity was invariably associated with the cytosolic localization of PKC, the mitochondrial accumulation of Bad, and a rapid MPT-dependent necrosis. All these events were prevented by nanomolar concentrations of the 5-LO product 5-hydroxyeicosatetraenoic acid.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338611253613,"sku":"KTE60834-48T","price":359.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338757071213,"sku":"KTE60834-96T","price":619.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338757103981,"sku":"KTE60834-96TX5","price":2809.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338757136749,"sku":"KTE60834-96TX50","price":26209.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60834.png?v=1778954704","url":"https:\/\/www.ebiohippo.com\/products\/human-5-hydroxyeicosatetraenoic-acid-5-hete-elisa-kit-bhe13703050","provider":"BioHippo","version":"1.0","type":"link"}