{"product_id":"human-af4-fmr2-family-member-1-aff1-elisa-kit-bhe13703170","title":"Human AF4\/FMR2 family member 1 (AFF1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman AF4\/FMR2 family member 1 (AFF1) ELISA Kit has high sensitivity and excellent specificity for detection of Human AFF1. No significant cross-reactivity or interference between Human AFF1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThe sequence of the complete open reading frame for this fusion transcript revealed that the MLL protein is homologous with DNA methyltransferase, the Drosophila trithorax gene product, and the 'AT-hook' motif of high mobility group proteins. An alternative splice that deletes the AT-hook region of MLL was identified. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus.\u003c\/p\u003e\u003cp\u003eThe composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant-negative mechanism in leukemogenesis. This gene is also symbolized MLLT2\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338615972205,"sku":"KTE60954-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338769719661,"sku":"KTE60954-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338769752429,"sku":"KTE60954-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338769785197,"sku":"KTE60954-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60954.png?v=1778954710","url":"https:\/\/www.ebiohippo.com\/products\/human-af4-fmr2-family-member-1-aff1-elisa-kit-bhe13703170","provider":"BioHippo","version":"1.0","type":"link"}