{"product_id":"human-alpha-2-macroglobulin-like-protein-1-a2ml1-elisa-kit-bhe13703058","title":"Human Alpha-2-macroglobulin-like protein 1 (A2ML1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Alpha-2-macroglobulin-like protein 1 (A2ML1) ELISA Kit has high sensitivity and excellent specificity for detection of Human A2ML1. No significant cross-reactivity or interference between Human A2ML1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThe alpha-macroglobulin (AM) superfamily of proteins contains both complement components and protease inhibitors, including A2M and A2ML1. AM proteins display a unique trap mechanism of inhibition, by which the AM inhibitor undergoes a major conformational change upon its cleavage by a protease, thus trapping the protease and blocking it from subsequent substrate binding. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates. Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338611941741,"sku":"KTE60842-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338757759341,"sku":"KTE60842-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338757792109,"sku":"KTE60842-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338757824877,"sku":"KTE60842-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60842.png?v=1778954700","url":"https:\/\/www.ebiohippo.com\/products\/human-alpha-2-macroglobulin-like-protein-1-a2ml1-elisa-kit-bhe13703058","provider":"BioHippo","version":"1.0","type":"link"}