{"product_id":"human-apoptosis-signal-regulating-kinase-1-ask-1-elisa-kit-bhe13703953","title":"Human Apoptosis signal regulating kinase 1 (ASK-1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Apoptosis signal regulating kinase 1 (ASK-1) ELISA Kit has high sensitivity and excellent specificity for detection of Human MAP3K5. No significant cross-reactivity or interference between Human MAP3K5 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eApoptosis signal-regulating kinase 1 is an enzyme which in humans is encoded by the MAP3K5 gene. This gene is located on chromosome 6 at locus 6q22.33 and the transcribed protein contains 1,374 amino acids with 11 kinase subdomains. The ASK1 (MAPKKK5) protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)\/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; ASK1 does not activate MAPK\/ERK.ASK1 found in the inactive form, bound to reduced thioredoxin.When oxidized by a reactive oxygen species, Trx dissociates from ASK1. The ASK1, which is found as a homo-oligodimer, autophosphorylates and becomes an active MAP kinase kinase kinase.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338641662317,"sku":"KTE61738-48T","price":359.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338846396781,"sku":"KTE61738-96T","price":619.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338846429549,"sku":"KTE61738-96TX5","price":2809.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338846462317,"sku":"KTE61738-96TX50","price":26209.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61738.png?v=1778954787","url":"https:\/\/www.ebiohippo.com\/products\/human-apoptosis-signal-regulating-kinase-1-ask-1-elisa-kit-bhe13703953","provider":"BioHippo","version":"1.0","type":"link"}