{"product_id":"human-beta-2-microglobulin-protein-bhp10506055","title":"human Beta-2-microglobulin protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative human beta-2-microglobulin (B2M) is purified from human urine and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Other Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eBeta-2-microglobulin (B2M) is the light chain component of MHC class I molecules and is required for stable cell-surface presentation of peptide-loaded MHC I. Because it can be shed or released, it is also commonly measured as a soluble protein in immunology and inflammation-focused studies.\u003c\/p\u003e\u003cp\u003eComponent of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eAntigen presentation and immunopeptidomics workflows where MHC I stability and surface expression are critical variables.\u003c\/li\u003e \u003cli\u003eImmune activation contexts (infection, inflammation, tumor microenvironment) where altered MHC I\/B2M biology can affect recognition.\u003c\/li\u003e \u003cli\u003eUse of soluble B2M measurements in translational research as a context marker (RUO; interpretation depends on system and matrix).\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eControls\/standards in immunoassays that quantify soluble B2M in biological samples.\u003c\/li\u003e \u003cli\u003eMechanistic studies of MHC class I assembly\/stability and antigen presentation concepts.\u003c\/li\u003e \u003cli\u003eReference reagent for antibody characterization and binding assays targeting B2M.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eCell-surface vs soluble pools reflect different biology; interpret measurements in the context of secretion\/shedding and sample matrix.\u003c\/li\u003e \u003cli\u003eMHC I expression is regulated by cytokines and cellular stress; changes in B2M-related readouts may be indirect.\u003c\/li\u003e \u003cli\u003eSpecies and allele context can matter for MHC-related workflows; align reagent choice with model organism.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=beta-2-microglobulin B2M - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=beta-2-microglobulin B2M - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=beta-2-microglobulin B2M%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 g","offer_id":53052978364781,"sku":"CSB-NP057841h-1G","price":173335.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53052978397549,"sku":"CSB-NP057841h-100MG","price":26665.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53052978430317,"sku":"CSB-NP057841h-10MG","price":3335.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052978463085,"sku":"CSB-NP057841h-1MG","price":630.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP057841h-SDS.jpg?v=1772166487","url":"https:\/\/www.ebiohippo.com\/products\/human-beta-2-microglobulin-protein-bhp10506055","provider":"BioHippo","version":"1.0","type":"link"}