{"product_id":"human-camp-dependent-protein-kinase-type-ii-beta-regulatory-subunit-prkar2b-elisa-kit-bhe13703366","title":"Human CAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman CAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) ELISA Kit has high sensitivity and excellent specificity for detection of Human PRKAR2B. No significant cross-reactivity or interference between Human PRKAR2B and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThe inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.\u003c\/p\u003e\u003cp\u003ePRKAR2b is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338622230893,"sku":"KTE61150-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338788921709,"sku":"KTE61150-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338788954477,"sku":"KTE61150-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338788987245,"sku":"KTE61150-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/human-camp-dependent-protein-kinase-type-ii-beta-regulatory-subunit-prkar2b-elisa-kit-bhe13703366","provider":"BioHippo","version":"1.0","type":"link"}