{"product_id":"human-carboxyterminal-propeptide-of-type-i-procollagen-picp-elisa-kit-bhe13703546","title":"Human Carboxyterminal propeptide of type I procollagen (PICP) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Carboxyterminal propeptide of type I procollagen (PICP) ELISA Kit has high sensitivity and excellent specificity for detection of Human PINP. No significant cross-reactivity or interference between Human PINP and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThe carboxyterminal propeptide of type I procollagen (PICP) and the aminoterminal propeptide of type I procollagen (PINP) are enzymatically removed from the procollagen molecule by specific proteases.\u003c\/p\u003e\u003cp\u003ePICP and PINP are indicators of the synthesis of type I collagen. Cleavage of PICP is required for the initiation of fibril formation, whereas PINP may be retained in the collagen molecule resulting in type I pN-collagen. The retention of PINP is transient, unlike the presence of IIIpN-collagen, and has been considered to regulate fibril diameter (Fleischmajer et al. 1985).\u003c\/p\u003e\u003cp\u003ePICP is a trimeric, globular protein consisting of three polypeptide chains: two proα1(I) and one proα2(I) chains. The molecular mass of PICP is 100 000 and it is cleared by mannose receptors in liver endothelial cells (Smedsrød et al. 1990).\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338628784493,"sku":"KTE61330-48T","price":359.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338806419821,"sku":"KTE61330-96T","price":619.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338806452589,"sku":"KTE61330-96TX5","price":2809.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338806485357,"sku":"KTE61330-96TX50","price":26209.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61330.png?v=1778954747","url":"https:\/\/www.ebiohippo.com\/products\/human-carboxyterminal-propeptide-of-type-i-procollagen-picp-elisa-kit-bhe13703546","provider":"BioHippo","version":"1.0","type":"link"}