{"product_id":"human-casein-bhp10506049","title":"Human casein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative human casein (CSN) is purified from human milk and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Storage Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eCaseins are a family of milk proteins characterized by relatively flexible, proline-rich sequences and extensive phosphorylation. They assemble into micellar structures with calcium phosphate, making them central to milk biology and widely studied in food science and biomaterials contexts.\u003c\/p\u003e\u003cp\u003eCasein contains a fairly high number of proline residues, which do not interact. There are also no disulfide bridges.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eMilk protein self-assembly and micelle structure research using advanced imaging and scattering approaches.\u003c\/li\u003e \u003cli\u003eBioactive peptide generation and functional ingredient research (RUO) that examines digestion-derived casein peptides.\u003c\/li\u003e \u003cli\u003eUse of casein-based materials (nanoparticles, films) as model soft-matter systems in delivery and formulation research.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eReference protein for studying intrinsically disordered or flexible protein behavior and calcium-dependent assembly.\u003c\/li\u003e \u003cli\u003eFood matrix analytics and method development where casein composition affects processing outcomes.\u003c\/li\u003e \u003cli\u003eBiomaterials research using casein as a biopolymer component.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eCasein preparations can include multiple isoforms and phosphorylation states; these may affect aggregation and binding.\u003c\/li\u003e \u003cli\u003eCalcium and ionic strength strongly influence micelle-like behavior; interpret assays with attention to buffer composition.\u003c\/li\u003e \u003cli\u003eBecause caseins are heterogeneous, quantitative comparisons benefit from well-defined standards and orthogonal characterization.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=casein CSN milk micelle - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=casein CSN milk micelle - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=casein CSN milk micelle%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"10 mg","offer_id":53052975186285,"sku":"CSB-NP008801h-10MG","price":3605.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052975219053,"sku":"CSB-NP008801h-1MG","price":450.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP008801h-SDS.jpg?v=1772166488","url":"https:\/\/www.ebiohippo.com\/products\/human-casein-bhp10506049","provider":"BioHippo","version":"1.0","type":"link"}