{"product_id":"human-complement-c4-bhp11006024","title":"Human Complement C4","description":"\u003cp\u003e\u003cstrong\u003eHuman Complement C4\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eNative human C4 is aglycosylated polypeptide containing 3 disulfide-linked chains. C4 is essential to the activation of both thelectin and the classical pathways of complement activation.Initiation of each pathway generates proteolytic enzyme complexes which are bound to the target surface. These enzymes cleave a peptide bond in C4 releasing the anaphylatoxin C4a and activating C4b. Like C3, the thioester of metastable C4b is highly reactive and is capable of reacting and covalently coupling C4b to amino or hydroxyl groups on the target surface. C4A and C4B are 2 variants of C4 that are common in manwhereas, in animals who have only 1 type usually have C4B.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHuman Virus Test:\u003c\/strong\u003e Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HTLV-I \u0026amp;II, STS and HBSAG.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"20 ug","offer_id":53038180237677,"sku":"pro-2688-20UG","price":220.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038540390765,"sku":"pro-2688-100UG","price":660.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038540423533,"sku":"pro-2688-1MG","price":3500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-c4-human-PRO-2688.png?v=1782158389","url":"https:\/\/www.ebiohippo.com\/products\/human-complement-c4-bhp11006024","provider":"BioHippo","version":"1.0","type":"link"}