{"product_id":"human-complement-c6-bhp11006029","title":"Human Complement C6","description":"\u003cp\u003e\u003cstrong\u003eHuman Complement C6\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eC6 is necessary for membrane attack complex formation and is activated by binding to recently-formed C5b at the cell membrane.Each pathway of complement activation generates proteolytic enzyme complexes which are bound to the target surface. These enzymes cleave a peptide bond in the larger alpha chain of C5 releasing C5a and activating C5b. Although C5b is unstable it remains bound to the activating complex for a few minutes during which it binds a single C6 from the surrounding fluid or it decays and is no longer capable of forming MAC. The C5b,6 complex may also remain connected to the C3\/C5 convertase where the binding of a single C7 exposes a membrane-binding region and C5b,6,7 can enter into the bilipid layer of the target cell.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHuman Virus Test:\u003c\/strong\u003e Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"20 ug","offer_id":53038181056877,"sku":"pro-2693-20UG","price":220.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038541242733,"sku":"pro-2693-100UG","price":660.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038541275501,"sku":"pro-2693-1MG","price":2750.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-c6-human-PRO-2693.png?v=1782158390","url":"https:\/\/www.ebiohippo.com\/products\/human-complement-c6-bhp11006029","provider":"BioHippo","version":"1.0","type":"link"}