{"product_id":"human-complement-component-4-binding-protein-bhp11006023","title":"Human Complement Component 4 Binding Protein","description":"\u003cp\u003e\u003cstrong\u003eHuman Complement Component 4 Binding Protein\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eC4BP has a flower shaped structure with each alpha chain radiating out from a central core. The arms are linked by disulfide bonds in the centre and the ends of each arm bind C4b. C4BP acts as a cofactor allowing factor I to split and permanently inactivate C4b. C4b binding protein modulates complement activation of the classical and lectin pathways. C4BP binds to C4b and accelerates the dissociation of C2a from the C3\/C5 convertase C4b,C2a. This inactivates the central enzyme of both pathways. Studies have shown that on surfaces densely coated with C4b, C4BP can bind up to four C4b molecules simultaneously.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHuman Virus Test:\u003c\/strong\u003e Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HTLV-I \u0026amp;II, STS and HBSAG.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"20 ug","offer_id":53038180532589,"sku":"pro-2734-20UG","price":220.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038540456301,"sku":"pro-2734-100UG","price":660.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038540489069,"sku":"pro-2734-1MG","price":3500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-c4bp-human-PRO-2734.png?v=1782158391","url":"https:\/\/www.ebiohippo.com\/products\/human-complement-component-4-binding-protein-bhp11006023","provider":"BioHippo","version":"1.0","type":"link"}