{"product_id":"human-complement-factor-h-bhp11006059","title":"Human Complement Factor H","description":"\u003cp\u003e\u003cstrong\u003eHuman Complement Factor H\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eComplement factor H (CFH) is an important regulatory component of the alternative pathway of complement. CFH is prevents complement activation on host cells and tissues, mainly the kidney. CFH controls the formation and decay of the alternative pathway C3\/C5 convertase and acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H . The N-terminal 5 domains of CFH bind to C3b and inhibit binding of factor B thus reducing the formation of C3\/C5 convertase. CFH also binds to preformed C3\/C5 convertases and causes quick release of the catalytic subunit Bb . These activities are necessary for controlling the spontaneous activation of the alternative pathway amplification process in plasma. In addition, CFH controls the formation and decay of these enzymes when C3b is attached to the surface of particles.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHuman Virus Test:\u003c\/strong\u003e Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"20 ug","offer_id":53038182138221,"sku":"pro-2700-20UG","price":220.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038542618989,"sku":"pro-2700-100UG","price":660.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038542651757,"sku":"pro-2700-1MG","price":2750.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-cfh-human-PRO-2700.png?v=1782158392","url":"https:\/\/www.ebiohippo.com\/products\/human-complement-factor-h-bhp11006059","provider":"BioHippo","version":"1.0","type":"link"}