{"product_id":"human-cutaneous-angiosarcoma-cell-line-ku-cas3-bhc10901739","title":"Human Cutaneous Angiosarcoma Cell Line (KU-CAS3)","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\n\u003cp\u003eThe KU-CAS3 cell line is a novel human cutaneous angiosarcoma model derived from scalp primary angiosarcoma tissue. KU-CAS3 shows endothelial cell properties, with cobblestone appearance at confluence.\u003c\/p\u003e\n\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eModel identity:\u003c\/strong\u003e Human Cutaneous Angiosarcoma Cell Line (KU-CAS3) is supplied as a tumor cell line derived from Human skin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth properties:\u003c\/strong\u003e Adherent, Polygonal; Morphology changes to cobblestone with contact inhibition.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth conditions:\u003c\/strong\u003e PriCoat™ T25 Flasks (G299) coated with Gelatin Coating Solution (0.1%) (TM063) are required for optimal cell adhesion and growth. The base medium for this cell line is Prigrow X Series Medium (TM8028) + 1% Penicillin\/Streptomycin Solution (G255), 37.0°C, 5% CO₂.Note: Cells are sensitive to trypsin; Gentle Dissociation Solution (TM080) is recommended for subculture procedures. Morphology will change with contact inhibition; subculture cells when 60-70% confluent.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProduct format:\u003c\/strong\u003e Frozen, BSL-2\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis cell-based model is generally used in vascular biology, signaling, and assay development studies. Donor\/background information is available for contextual interpretation.\u003c\/p\u003e\n\u003ch2\u003eBiological background\u003c\/h2\u003e\n\u003cp\u003eThese cells are CD31 positive, display tube forming activity, actively uptake LDL, express vWF, show high levels of adrenergic β2 receptor, VEGF1 and VEGF2 receptors. STR profiliing was used for cell line authentication. These cells have tumorigenic potential in vivo and are suitable for cutaneous angiosarcoma research. Additional cell lines from this panel:Cat. T8029 - Human Cutaneous Angiosarcoma Cell Line (KU-CAS5) Donor\/background information provided for this product: Male, 73, Korean, Scalp Primary Angiosarcoma.\u003c\/p\u003e\n\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCell-line models continue to be used for tumor phenotype comparison, pathway perturbation studies, and assay development in controlled in vitro systems.\u003c\/li\u003e\n\u003cli\u003eEngineered and subtype-defined tumor lines are often used to compare growth behavior, reporter output, and response patterns across matched experimental conditions.\u003c\/li\u003e\n\u003cli\u003eWhen metastatic or lineage features are described, investigators commonly interpret results alongside morphology, passage history, and culture environment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCommon research applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eCancer biology studies that compare proliferation-associated behavior, morphology, and pathway responses in vitro.\u003c\/li\u003e\n\u003cli\u003eAssay development for treatment response, reporter monitoring, or phenotype comparison under matched culture conditions.\u003c\/li\u003e\n\u003cli\u003eSide-by-side comparison of engineered versus parental background characteristics when relevant to the study design.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eChanges in morphology, growth rate, viability, or reporter signal are typically interpreted together with passage history, culture matrix, and the specified growth conditions for the model.\u003c\/p\u003e\n\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eMorphology, doubling behavior, and reporter or marker output can shift with passage number, substrate choice, and medium composition; these variables should be recorded alongside experimental readouts.\u003c\/li\u003e\n\u003cli\u003eMatched controls such as parental cells, untreated cultures, or parallel cultures maintained under identical conditions help distinguish background effects from biology of interest.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eCulture and product details\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth Conditions:\u003c\/strong\u003e PriCoat™ T25 Flasks (G299) coated with Gelatin Coating Solution (0.1%) (TM063) are required for optimal cell adhesion and growth. The base medium for this cell line is Prigrow X Series Medium (TM8028) + 1% Penicillin\/Streptomycin Solution (G255), 37.0°C, 5% CO₂.Note: Cells are sensitive to trypsin; Gentle Dissociation Solution (TM080) is recommended for subculture procedures. Morphology will change with contact inhibition; subculture cells when 60-70% confluent.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSeeding Density (cells\/cm²):\u003c\/strong\u003e 7000-8000\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Applied Biological Materials (abm) Inc.","offers":[{"title":"1x10\u003csup\u003e6\u003c\/sup\u003e cells \/ 1.0 ml","offer_id":53180534849901,"sku":"T8028","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/GgImVkh0gkExv5d5gghBiBCBRKNNtgIJvi9vdLRY.png?v=1774957842","url":"https:\/\/www.ebiohippo.com\/products\/human-cutaneous-angiosarcoma-cell-line-ku-cas3-bhc10901739","provider":"BioHippo","version":"1.0","type":"link"}