{"product_id":"human-cystatin-c-protein-bhp10506056","title":"human Cystatin-C protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative human cystatin C (CST3) is purified from human urine and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Other Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eCystatin C (CST3) is a secreted cysteine protease inhibitor that regulates extracellular and lysosomal protease activity. It is broadly expressed and has been extensively studied in the context of protease balance, tissue remodeling, and inflammatory signaling.\u003c\/p\u003e\u003cp\u003eAs an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level).\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eProtease–antiprotease balance studies in inflammation and tissue remodeling, including cathepsin pathway regulation.\u003c\/li\u003e \u003cli\u003eSystems biology approaches that use cystatin C as a context marker in renal physiology and protein turnover research (RUO).\u003c\/li\u003e \u003cli\u003eNeuroinflammation and neurodegeneration research exploring extracellular proteostasis and protease regulation.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eStandards\/controls for immunoassays that quantify cystatin C in biological matrices.\u003c\/li\u003e \u003cli\u003eBiochemical inhibition studies of cysteine proteases (conceptual; no protocol steps).\u003c\/li\u003e \u003cli\u003eMechanistic work linking protease activity to extracellular matrix remodeling and signaling.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eProtease inhibition readouts can be influenced by pH, redox state, and competing substrates; interpret in context.\u003c\/li\u003e \u003cli\u003eCystatin C is secreted and can associate with extracellular compartments; sample handling and matrix choice affect measurements.\u003c\/li\u003e \u003cli\u003eSpecies differences and isoforms can affect antibody recognition; match reagent\/species to your assay design.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=cystatin C CST3 - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=cystatin C CST3 - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=cystatin C CST3%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 g","offer_id":53052975841645,"sku":"CSB-NP061941h-1G","price":266665.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53052975874413,"sku":"CSB-NP061941h-100MG","price":34665.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53052975907181,"sku":"CSB-NP061941h-10MG","price":4665.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052975939949,"sku":"CSB-NP061941h-1MG","price":630.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP061941h-SDS.jpg?v=1772166487","url":"https:\/\/www.ebiohippo.com\/products\/human-cystatin-c-protein-bhp10506056","provider":"BioHippo","version":"1.0","type":"link"}