{"product_id":"human-dna-binding-protein-satb1-satb1-elisa-kit-bhe13702965","title":"Human DNA-binding protein SATB1 (SATB1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman DNA-binding protein SATB1 (SATB1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SATB1. No significant cross-reactivity or interference between Human SATB1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eSATB1, the global chromatin organizer and transcription factor, has emerged as a key factor integrating higher-order chromatin architecture with gene regulation. Recent studies have unraveled the role of SATB1 in organization of chromatin 'loopscape' and its dynamic nature in response to physiological stimuli. At genome-wide level, SATB1 seems to play a role in organization of the transcriptionally poised chromatin. SATB1 organizes the MHC class-I locus into distinct chromatin loops by tethering MARs to nuclear matrix at fixed distances. Silencing of SATB1 mimics the effects of IFN-γ treatment on chromatin loop architecture of the MHC class I locus and altered expression of genes within the locus. SATB1induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338608894317,"sku":"KTE60749-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338749305197,"sku":"KTE60749-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338749337965,"sku":"KTE60749-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338749370733,"sku":"KTE60749-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60749.png?v=1778954689","url":"https:\/\/www.ebiohippo.com\/products\/human-dna-binding-protein-satb1-satb1-elisa-kit-bhe13702965","provider":"BioHippo","version":"1.0","type":"link"}