{"product_id":"human-e3-ubiquitin-protein-ligase-mdm2-mdm2-elisa-kit-bhe13703891","title":"Human E3 ubiquitin-protein ligase Mdm2 (MDM2) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman E3 ubiquitin-protein ligase Mdm2 (MDM2) ELISA Kit has high sensitivity and excellent specificity for detection of Human MDM2. No significant cross-reactivity or interference between Human MDM2 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMDM2 encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for MDM2 on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338640548205,"sku":"KTE61676-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338840596845,"sku":"KTE61676-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338840629613,"sku":"KTE61676-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338840662381,"sku":"KTE61676-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61676.png?v=1778954782","url":"https:\/\/www.ebiohippo.com\/products\/human-e3-ubiquitin-protein-ligase-mdm2-mdm2-elisa-kit-bhe13703891","provider":"BioHippo","version":"1.0","type":"link"}